Faculty of Biomedical Engineering, Silesian University of Technology, 41-800 Zabrze, Poland.
Division of Neurological and Psychiatric Nursing, Faculty of Health Sciences, Medical University of Gdansk, 80-211 Gdansk, Poland.
Sensors (Basel). 2022 Feb 21;22(4):1688. doi: 10.3390/s22041688.
Parkinson's disease (PD) and progressive supranuclear palsy (PSP) are neurodegenerative movement disorders associated with cognitive dysfunction. The Luria's Alternating Series Test (LAST) is a clinical tool sensitive to both graphomotor problems and perseverative tendencies that may suggest the dysfunction of prefrontal and/or frontostriatal areas and may be used in PD and PSP assessment. It requires the participant to draw a series of alternating triangles and rectangles. In the study, two clinical groups-51 patients with PD and 22 patients with PSP-were compared to 32 neurologically intact seniors. Participants underwent neuropsychological assessment. The LAST was administered in a paper and pencil version, then scanned and preprocessed. The series was automatically divided into characters, and the shapes were recognized as rectangles or triangles. In the feature extraction step, each rectangle and triangle was regarded both as an image and a two-dimensional signal, separately and as a part of the series. Standard and novel features were extracted and normalized using characters written by the examiner. Out of 71 proposed features, 51 differentiated the groups ( < 0.05). A classifier showed an accuracy of 70.5% for distinguishing three groups.
帕金森病（PD）和进行性核上性麻痹（PSP）是与认知功能障碍相关的神经退行性运动障碍。Luria 交替系列测试（LAST）是一种临床工具，对书写运动问题和固执倾向敏感，可能提示前额叶和/或额纹状体区域的功能障碍，可用于 PD 和 PSP 的评估。它要求参与者绘制一系列交替的三角形和矩形。在这项研究中，将两个临床组-51 名 PD 患者和 22 名 PSP 患者与 32 名神经功能正常的老年人进行了比较。参与者接受了神经心理学评估。LAST 以纸笔形式进行，然后进行扫描和预处理。系列被自动分为字符，形状被识别为矩形或三角形。在特征提取步骤中，每个矩形和三角形既被视为图像，也被视为二维信号，分别作为序列的一部分。使用检查者书写的字符对标准和新颖特征进行提取和归一化。在所提出的 71 个特征中，有 51 个特征可以区分这三个组（<0.05）。分类器对区分三组的准确率为 70.5%。
