School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
Int J Mol Sci. 2022 Feb 14;23(4):2118. doi: 10.3390/ijms23042118.
Actin-associated proteins (AAPs) act on monomeric globular actin (G-actin) and polymerized filamentous actin (F-actin) to regulate their dynamics and architectures which ultimately control cell movement, shape change, division; organelle localization and trafficking. Actin-binding proteins (ABPs) are a subset of AAPs. Since actin was discovered as a myosin-activating protein (hence named actin) in 1942, the protein has also been found to be expressed in non-muscle cells, and numerous AAPs continue to be discovered. This review article lists all of the AAPs discovered so far while also allowing readers to sort the list based on the names, sizes, functions, related human diseases, and the dates of discovery. The list also contains links to the UniProt and Protein Atlas databases for accessing further, related details such as protein structures, associated proteins, subcellular localization, the expression levels in cells and tissues, mutations, and pathology. Because the actin cytoskeleton is involved in many pathological processes such as tumorigenesis, invasion, and developmental diseases, small molecules that target actin and AAPs which hold potential to treat these diseases are also listed.
肌动蛋白相关蛋白 (AAPs) 作用于单体球状肌动蛋白 (G-actin) 和聚合丝状肌动蛋白 (F-actin)，以调节它们的动态和结构，从而最终控制细胞运动、形态变化、分裂；细胞器定位和运输。肌动蛋白结合蛋白 (ABPs) 是 AAPs 的一个子集。自 1942 年肌动蛋白被发现作为肌球蛋白激活蛋白（因此命名为肌动蛋白）以来，还发现它在非肌肉细胞中表达，并且不断发现新的 AAPs。这篇综述文章列出了迄今为止发现的所有 AAPs，同时还允许读者根据名称、大小、功能、相关人类疾病以及发现日期对列表进行排序。该列表还包含指向 UniProt 和 Protein Atlas 数据库的链接，可用于访问更多相关详细信息，如蛋白质结构、相关蛋白质、亚细胞定位、细胞和组织中的表达水平、突变和病理学。由于肌动蛋白细胞骨架参与许多病理过程，如肿瘤发生、侵袭和发育性疾病，因此还列出了靶向肌动蛋白和 AAPs 的小分子，这些小分子具有治疗这些疾病的潜力。
