Department of Biomedical Sciences of Cells & Systems, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Department of Biomedical Sciences of Cells & Systems, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Lancet Psychiatry. 2022 Apr;9(4):330-336. doi: 10.1016/S2215-0366(21)00383-7. Epub 2022 Feb 23.
Women with a schizophrenia-spectrum disorder (SSD) have a better clinical profile than do men at the start of their illness but progress to the same state within the first few years of living with SSD. There are benefits to be gained across different areas in the care currently offered to women with psychosis. An important point for improvement is the early detection of female-specific signs of a first episode of psychosis, to shorten the duration of untreated psychosis, with prompt access to early intervention services. Special attention should be paid to sexual health, and to any history of childhood trauma. Antipsychotics require dosing and prescription tailored to the female physiology that consider hormonal life phases such as menopause. Switching to prolactin-sparing medications can benefit both mental and somatic health. Finally, hormone replacement therapy should be considered for postmenopausal women. By providing female-specific care, women with schizophrenia-spectrum disorders will have optimal chances to fare well.
女性精神分裂症谱系障碍（SSD）患者在发病初期的临床特征优于男性，但在 SSD 发病后的最初几年内，病情进展到相同状态。在目前为精神分裂症女性患者提供的护理的不同领域都存在获益的机会。需要改进的一个重要方面是早期发现女性首发精神病的特定迹象，以缩短未治疗精神病的持续时间，并尽快获得早期干预服务。应特别关注性健康以及任何儿童期创伤的病史。抗精神病药物的剂量和处方需要根据女性的生理特征进行调整，以考虑到如更年期等激素生命阶段。改用不引起催乳素升高的药物可能有益于精神和躯体健康。最后，应考虑为绝经后妇女提供激素替代疗法。通过提供女性特定的护理，精神分裂症谱系障碍的女性将有最佳的机会获得良好的预后。
