性腺功能减退男性的生育相关考量

Fertility Considerations in Hypogonadal Men.

作者信息

Papanikolaou Nikoleta, Luo Rong, Jayasena Channa N

机构信息

Section of Investigative Medicine Imperial College London, Hammersmith Hospital, 6th Floor, Commonwealth Building, 150 Du Cane Road, London W12 0NN, UK.

出版信息

Endocrinol Metab Clin North Am. 2022 Mar;51(1):133-148. doi: 10.1016/j.ecl.2021.11.009. Epub 2022 Feb 8.

DOI:10.1016/j.ecl.2021.11.009

PMID:35216712

Abstract

Hypogonadism can be present in up to 40% in men who present with couple infertility. Testosterone is the major androgen regulating-spermatogenesis in men; as a result, men with either primary or secondary hypogonadism may be subfertile because of impaired spermatogenesis. The clinical impact of hypogonadism on fertility potential depends on the timing of its onset (fetal, prepubertal, or postpubertal) and effect on semen parameters. Treatment pathways and success rates differ according to the cause of hypogonadism and the time of its onset. When medical therapy fails to induce sufficient sperm, assisted reproductive technologies are considered.

摘要

在患有夫妻不育症的男性中，性腺功能减退的发生率可能高达40%。睾酮是调节男性精子发生的主要雄激素；因此，原发性或继发性性腺功能减退的男性可能因精子发生受损而生育力低下。性腺功能减退对生育潜力的临床影响取决于其发病时间（胎儿期、青春期前或青春期后）以及对精液参数的影响。根据性腺功能减退的病因及其发病时间，治疗途径和成功率各不相同。当药物治疗未能诱导出足够的精子时，可考虑采用辅助生殖技术。