Peto T E, Thompson J L
Br J Haematol. 1986 Jun;63(2):273-80. doi: 10.1111/j.1365-2141.1986.tb05550.x.
It has been suggested that P. falciparum takes up iron from serum and that desferrioxamine, an iron chelating agent, inhibits parasite growth. We have now shown, however, that when all the iron is transferrin bound, P. falciparum, in culture, takes up less than 7 pmol Fe/10(9) parasites/24 h and that incorporation is increased only in the presence of a high molecular weight iron complex not naturally found in serum. Furthermore, removal of iron serum did not reduce parasite growth, and addition of excess iron was inhibitory. Desferrioxamine inhibited growth, but this inhibition was reduced under conditions in which the transfer of iron from transferrin to desferrioxamine was accelerated. We conclude that P. falciparum does not directly utilize serum iron and that desferrioxamine does not inhibit the parasite by interfering with the supply of iron from the incubation medium. The results are relevant to clinical data which suggest that added nutritional iron enhances the host susceptibility to malaria.
有人提出恶性疟原虫从血清中摄取铁，并且去铁胺（一种铁螯合剂）会抑制寄生虫生长。然而，我们现在已经表明，当所有的铁都与转铁蛋白结合时，培养中的恶性疟原虫每24小时每10⁹个寄生虫摄取的铁少于7皮摩尔，而且只有在存在血清中天然不存在的高分子量铁复合物时，铁的掺入量才会增加。此外，去除血清铁并不会降低寄生虫的生长，而添加过量的铁则具有抑制作用。去铁胺抑制生长，但在加速铁从转铁蛋白转移到去铁胺的条件下，这种抑制作用会减弱。我们得出结论，恶性疟原虫不直接利用血清铁，并且去铁胺不是通过干扰来自培养介质的铁供应来抑制寄生虫的。这些结果与临床数据相关，临床数据表明补充营养性铁会增强宿主对疟疾的易感性。
