Department of Population Health and Pathobiology, North Carolina State University, Raleigh, NC, USA.
Department of Population Health and Pathobiology, North Carolina State University, Raleigh, NC, USA.
Anaerobe. 2022 Apr;74:102541. doi: 10.1016/j.anaerobe.2022.102541. Epub 2022 Feb 22.
Clostridioides difficile is the leading cause of infectious diarrhea and one of the most common healthcare-acquired infections worldwide. We performed a systematic search and a bibliometric analysis of mathematical and computational models for Clostridioides difficile transmission. We identified 33 publications from 2009 to 2021. Models have underscored the importance of asymptomatic colonized patients in maintaining transmission in health-care settings. Infection control, antimicrobial stewardship, active testing, and vaccination have often been evaluated in models. Despite active testing and vaccination being not currently implemented, they are the most commonly evaluated interventions. Some aspects of C. difficile transmission, such community transmission and interventions in health-care settings other than in acute-care hospitals, remained less evaluated through modeling.
艰难梭菌是感染性腹泻的主要原因，也是全球最常见的医院获得性感染之一。我们对艰难梭菌传播的数学和计算模型进行了系统检索和文献计量分析。我们从 2009 年至 2021 年确定了 33 篇文献。模型强调了无症状定植患者在医疗机构中维持传播的重要性。感染控制、抗菌药物管理、主动检测和疫苗接种经常在模型中进行评估。尽管目前尚未实施主动检测和疫苗接种，但它们是最常评估的干预措施。艰难梭菌传播的某些方面，如社区传播以及急性护理医院以外的医疗机构中的干预措施，通过建模得到的评估仍然较少。
