Sieber F, Rao S, Rowley S D, Sieber-Blum M
Blood. 1986 Jul;68(1):32-6.
Cells from three different human neuroblastoma cell lines and normal human bone marrow cells were exposed to the lipophilic fluorescent dye, merocyanine 540 (MC 540), and white light. In vitro clonogenic tumor cells were inactivated up to 25,000 times more rapidly than multipotent hematopoietic progenitor cells (CFU-GEMM). It is conceivable that this pronounced difference in sensitivity to MC 540-mediated photolysis can be exploited for the selective killing of residual neuroblastoma cells in autologous remission marrow grafts.
来自三种不同人类神经母细胞瘤细胞系的细胞以及正常人骨髓细胞被暴露于亲脂性荧光染料部花青540（MC 540）和白光下。体外克隆形成的肿瘤细胞比多能造血祖细胞（CFU-GEMM）更快失活达25000倍之多。可以想象，这种对MC 540介导的光解敏感性的显著差异可用于选择性杀死自体缓解期骨髓移植中残留的神经母细胞瘤细胞。
