部花青540介导的光致敏对白血病细胞的选择性杀伤作用
Selective killing of leukemic cells by merocyanine 540-mediated photosensitization.
作者信息
Sieber F, Spivak J L, Sutcliffe A M
出版信息
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7584-7. doi: 10.1073/pnas.81.23.7584.
Abstract
In vitro incubation of leukemic bone marrow with the lipophilic fluorescent dye merocyanine 540 and simultaneous exposure to light reduced the concentration of L1210 leukemia cells by about 5 orders of magnitude but spared enough normal pluripotent hematopoietic stem cells to allow hematopoietic reconstitution of lethally irradiated syngeneic mice. This simple and rapid procedure may find an application in the purging of tumor cells from autologous bone marrow grafts.
摘要
用亲脂性荧光染料部花青540对白血病骨髓进行体外培养，并同时暴露于光照下，可使L1210白血病细胞的浓度降低约5个数量级，但保留了足够数量的正常多能造血干细胞，从而使受致死剂量照射的同基因小鼠实现造血重建。这一简单快速的程序可能在从自体骨髓移植物中清除肿瘤细胞方面找到应用。
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