Department of Translational Medicine, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy.
Nuclear Medicine Unit, Oncological Medical and Specialists Department, University Hospital of Ferrara, Ferrara, Italy.
J Cancer Res Clin Oncol. 2022 Jun;148(6):1299-1311. doi: 10.1007/s00432-022-03958-7. Epub 2022 Feb 25.
Renal masses detection is continually increasing worldwide, with Renal Cell Carcinoma (RCC) accounting for approximately 90% of all renal cancers and remaining one of the most aggressive urological malignancies. Despite improvements in cancer management, accurate diagnosis and treatment strategy of RCC by computed tomography (CT) and magnetic resonance imaging (MRI) are still challenging. Prostate-Specific Membrane Antigen (PSMA) is known to be highly expressed on the endothelial cells of the neovasculature of several solid tumors other than prostate cancer, including RCC. In this context, recent preliminary studies reported a promising role for positron emission tomography (PET)/CT with radiolabeled molecules targeting PSMA, in alternative to fluorodeoxyglucose (FDG) in RCC patients.
The aim of our review is to provide an updated overview of current evidences and major limitations regarding the use of PSMA PET/CT in RCC.
A literature search, up to 31 December 2021, was performed using the following electronic databases: PubMed, SCOPUS, Web of Science, and Google Scholar.
The findings of this review suggest that PSMA PET/CT could represent a valid imaging option for diagnosis, staging, and therapy response evaluation in RCC, particularly in clear cell RCC.
Further studies are needed for this "relatively" new imaging modality to consolidate its indications, timing, and practical procedures.
全球范围内肾肿瘤的检测不断增加，其中肾细胞癌（RCC）约占所有肾癌的 90%，仍然是最具侵袭性的泌尿系统恶性肿瘤之一。尽管癌症管理有所改善，但计算机断层扫描（CT）和磁共振成像（MRI）对 RCC 的准确诊断和治疗策略仍然具有挑战性。前列腺特异性膜抗原（PSMA）已知在除前列腺癌以外的几种实体肿瘤的新生血管内皮细胞上高度表达，包括 RCC。在这种情况下，最近的初步研究报告称，针对 PSMA 的放射性标记分子的正电子发射断层扫描（PET）/CT 在 RCC 患者中替代氟脱氧葡萄糖（FDG）具有有前途的作用。
我们综述的目的是提供有关 PSMA PET/CT 在 RCC 中应用的最新证据和主要局限性的概述。
截至 2021 年 12 月 31 日，使用以下电子数据库进行文献检索：PubMed、SCOPUS、Web of Science 和 Google Scholar。
本综述的结果表明，PSMA PET/CT 可能是 RCC 诊断、分期和治疗反应评估的有效影像学选择，特别是在透明细胞 RCC 中。
需要进一步研究这种“相对”新的成像方式，以巩固其适应证、时机和实际操作程序。
