Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.
Institute for Human Genetics, Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein, Kiel, Germany.
Genes Chromosomes Cancer. 2022 Jul;61(7):432-436. doi: 10.1002/gcc.23034. Epub 2022 Mar 29.
Deregulation of micro(mi)-RNAs is a common mechanism in tumorigenesis. We investigated the expression of 2083 miRNAs in T-cell prolymphocytic leukemia (T-PLL). Compared to physiologic CD4+ and CD8+ T-cell subsets, 111 miRNAs were differentially expressed in T-PLL. Of these, 33 belonged to miRNA gene clusters linked to cancer. Genomic variants affecting miRNAs were infrequent with the notable exception of copy number aberrations. Remarkably, we found strong upregulation of the miR-200c/-141 cluster in T-PLL to be associated with DNA hypomethylation and active promoter marks. Our findings suggest that copy number aberrations and epigenetic changes could contribute to miRNA deregulation in T-PLL.
miRNA 的失调是肿瘤发生的常见机制。我们研究了 T 细胞前淋巴细胞白血病 (T-PLL) 中 2083 个 miRNA 的表达情况。与生理 CD4+和 CD8+T 细胞亚群相比，T-PLL 中 111 个 miRNA 的表达存在差异。其中，33 个属于与癌症相关的 miRNA 基因簇。影响 miRNA 的基因组变异很少见，除了拷贝数异常。值得注意的是，我们发现 T-PLL 中 miR-200c/-141 簇的强烈上调与 DNA 低甲基化和活跃的启动子标记有关。我们的研究结果表明，拷贝数异常和表观遗传变化可能导致 T-PLL 中 miRNA 的失调。
