Richards P D, Flaum M A, Bateman M, Kardinal C G
Cancer. 1986 Aug 15;58(4):959-62. doi: 10.1002/1097-0142(19860815)58:4<959::aid-cncr2820580426>3.0.co;2-z.
The efficacy of secobarbital sodium plus chlorpromazine (SC) in the prevention of cisplatin induced emesis was compared to the combination of metoclopramide, diphenhydramine, and dexamethasone (MDD). Twenty-three patients were entered onto protocol. Eighteen were evaluable. Good to excellent antiemetic prophylaxis was obtained in 72% with MDD versus 17% with SC (P less than 0.01). Sedation and anticholinergic side effects were more common with SC. Extrapyramidal reactions were more commonly seen with MDD. Significantly more patients preferred the combination of metoclopramide, diphenhydramine, and dexamethasone (P less than 0.05).
将司可巴比妥钠加氯丙嗪（SC）预防顺铂所致呕吐的疗效与胃复安、苯海拉明和地塞米松联合用药（MDD）的疗效进行了比较。23例患者进入研究方案。18例可进行评估。MDD组72%的患者获得了良好至极佳的止吐预防效果，而SC组为17%（P<0.01）。SC组镇静和抗胆碱能副作用更为常见。MDD组锥体外系反应更为常见。明显更多的患者更喜欢胃复安、苯海拉明和地塞米松的联合用药（P<0.05）。
