Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Purinergic Signal. 2023 Mar;19(1):199-206. doi: 10.1007/s11302-022-09851-9. Epub 2022 Feb 26.
Inflammation is one of the potential factors to cause the damage of ocular surface in dry eye disease (DED). Increasing evidence indicated that purinergic A, A, A, P2X4, P2X7, P2Y, P2Y, and P2Y receptors play an important role in the regulation of inflammation in DED: A adenosine receptor (A) is a systemic pro-inflammatory factor; A is involved in the activation of the MAPK/NF-kB pathway; A combined with inhibition of adenylate cyclase and regulation of the mitogen-activated protein kinase (MAPK) pathway leads to regulation of transcription; P2X4 promotes receptor-associated activation of pro-inflammatory cytokines and inflammatory vesicles; P2X7 promotes inflammasome activation and release of pro-inflammatory cytokines IL-1β and IL-18; P2Y receptors affect the phospholipase C(PLC)/IP3/Ca signaling pathway and mucin secretion. These suggested that purinergic receptors would be promising targets to control the inflammation of DED in the future.
炎症是导致干眼（DED）眼表损伤的潜在因素之一。越来越多的证据表明，嘌呤能 A、A、A、P2X4、P2X7、P2Y、P2Y 和 P2Y 受体在 DED 中的炎症调节中发挥重要作用：A 腺苷受体（A）是一种全身性促炎因子；A 参与 MAPK/NF-kB 途径的激活；A 与抑制腺苷酸环化酶和调节丝裂原激活蛋白激酶（MAPK）途径相结合，导致转录调节；P2X4 促进受体相关的促炎细胞因子和炎症小体的激活；P2X7 促进炎性体的激活和促炎细胞因子 IL-1β 和 IL-18 的释放；P2Y 受体影响磷脂酶 C（PLC）/IP3/Ca 信号通路和粘蛋白分泌。这表明嘌呤能受体可能成为未来控制 DED 炎症的有前途的靶点。
