Zhou Xiao-Ling, Du Yan-Hua, Chen Xiao-Hui, Liu Wen-Ying, Huang Yu-Mei
The People's Hospital of Longhua District, Shenzhen 518110, Guangdong Province, China.
Zhen Ci Yan Jiu. 2022 Feb 25;47(2):165-70. doi: 10.13702/j.1000-0607.201094.
To explore the clinical effect of Pinggan Jiangya decoction combined with penetrating needling at Baihui (GV20) in a period of day from 7 am to 9 am in the treatment of grade 1 and 2 essential hypertension (EH).
A total of 150 cases of grade 1 and 2 EH patients were randomized into an observation group and a control group, 75 cases in each group. In the control group, Pinggan Jiangya decoction was prescribed for oral administration one dose a day, while in the observation group, on the basis of the treatment as the control group, penetrating needling was exerted at GV20 once daily. The treatment duration was 8 weeks. Before and after treatment, the TCM syndrome score, 24 h average systolic blood pressure (24 h ASBP), 24 h average diastolic blood pressure (24 h ADBP), 24 h average pulse pressure difference (24 h PP), morning blood pressure surge (MBPS), 24 h SBP variability (24 h SBPV), 24 h DBP variability (24 h DBPV), serum levels of 5-hydroxytryptamine (5-HT) and melatonin (MT) were compared in the patients of the two groups. The clinical therapeutic effect was observed in the two groups.
After the treatment, in the self-comparison of each group, the scores of headache, vertigo, backache, soft knees, tinnitus, 24 h ASBP， 24 h ADBP, 24 h PP, MBPS, 24 h SBPV and 24 h DBPV in the two groups were lower than those before treatment (<0.01), and the above indexes in the observation group were lower than those in the control group (<0.01). The level of serum 5-HT after the treatment was lower than that of before the treatment (<0.01), while the level of MT was higher than that of before the treatment (<0.01) in both two groups, and the level of 5-HT in the observation group was lower than that of the control group, while the level of MT was higher than that of the control group (<0.01). The total effective rate of the observation group was 93.3% (70/75), better than 76.0% (57/75) of the control group (<0.01).
Pinggan Jiangya decoction combined with penetrating needling at GV20 in a period of day from 7 am to 9 am can regulate the levels of serum MT and 5-HT, effectively reduce blood pressure, improve blood pressure variability, control morning peak blood pressure, and has a remarkable effect in the treatment of grade 1 and 2 EH.
探讨平肝降压汤联合上午7时至9时百会穴（GV20）透刺治疗1、2级原发性高血压（EH）的临床疗效。
将150例1、2级EH患者随机分为观察组和对照组，每组75例。对照组给予平肝降压汤口服，每日1剂；观察组在对照组治疗基础上，每日上午7时至9时对GV20进行透刺治疗。疗程为8周。比较两组患者治疗前后的中医证候积分、24小时平均收缩压（24 h ASBP）、24小时平均舒张压（24 h ADBP）、24小时平均脉压差（24 h PP）、晨峰血压（MBPS）、24小时收缩压变异性（24 h SBPV）、24小时舒张压变异性（24 h DBPV）、血清5-羟色胺（5-HT）和褪黑素（MT）水平，并观察两组的临床疗效。
治疗后，两组组内自身比较，头痛、眩晕、腰酸、膝软、耳鸣、24 h ASBP、24 h ADBP、24 h PP、MBPS、24 h SBPV及24 h DBPV评分均低于治疗前（<0.01），且观察组上述指标低于对照组（<0.01）。两组治疗后血清5-HT水平低于治疗前（<0.01），MT水平高于治疗前（<0.01），且观察组5-HT水平低于对照组，MT水平高于对照组（<0.01）。观察组总有效率为93.3%（70/75），优于对照组的76.0%（57/75）（<0.01）。
平肝降压汤联合上午7时至9时GV20透刺能调节血清MT和5-HT水平，有效降低血压，改善血压变异性，控制晨峰血压，对1、2级EH治疗效果显著。
