Yuncheng Central Hospital, Hedong Street, Yanhu District, Yuncheng City, Shanxi Province, China.
Pak J Pharm Sci. 2022 Jan;35(1(Special)):365-368.
To explore the effect of Jiawei Qingxuan Jiangya Decoction on blood pressure variability and sex hormone levels in perimenopausal women with hypertension. A total of 400 perimenopausal female hypertensive patients admitted to the hospital from June 2019 to June 2020 were randomly divided into observation group and control group, with 200 cases in each group. The patients in the control group took orally benazepril hydrochloride tablets, and the observation group was added with Jiawei Qingxuan Jiangya Decoction on the basis of the control group. The course of treatment was 1 month. The clinical efficacy of the two groups and the 24h blood pressure variability (BPV) and sex hormone levels before and after treatment were compared. The total effective rate of the observation group was significantly higher than that of the control group (P<0.05); the 24h BPV of the two groups after treatment was significantly lower than that before the treatment, and the reduction in the observation group was greater (P<0.05); the serum estradiol in the observation group after treatment was significantly increased, and the level of follicle stimulating hormone was significantly reduced, and compared with the control group after treatment, the difference was statistically significant (P<0.05). Jiawei Qingxuan Jiangya Decoction for treating hypertension in perimenopausal women can effectively reduce blood pressure, improve short-term blood pressure variability, regulate sex hormone levels to a certain extent, and correct endocrine disorders. It is worthy of clinical promotion.
探讨加味青眩降压汤对围绝经期女性高血压患者血压变异性及性激素水平的影响。选取 2019 年 6 月至 2020 年 6 月我院收治的 400 例围绝经期女性高血压患者为研究对象，采用随机数字表法将其分为观察组和对照组，每组 200 例。对照组患者口服盐酸贝那普利片，观察组在对照组基础上加用加味青眩降压汤，疗程均为 1 个月。比较两组患者的临床疗效及治疗前后 24 h 血压变异性（BPV）和性激素水平。观察组总有效率明显高于对照组（P<0.05）；两组治疗后 24 h BPV 均明显低于治疗前，且观察组降低幅度更大（P<0.05）；观察组治疗后血清雌二醇明显升高，卵泡刺激素水平明显降低，与对照组治疗后比较差异有统计学意义（P<0.05）。加味青眩降压汤治疗围绝经期女性高血压可有效降低血压，改善短期血压变异性，在一定程度上调节性激素水平，纠正内分泌紊乱，值得临床推广。
