Eckstein K L, Vicente-Eckstein A, Steiner R, Missler U
Anaesthesist. 1978 May;27(5):suppl 27-31.
One hundred and forty-one patients for general and urological surgery were anaesthetized by epidural anesthesia (PDA) using bupivacaine-CO2 0.5% solutions. A frequency peak for the initial dose between 21-23 ml was noted. The response time and latency period were found to be 2.99 +/- 1.40 min and 11.02 +/- 3.66 min (smallest time unit 0.5 min). The effective duration was 5.02 +/- 0.93 h. The sensory spread reached on average to T 6.06 +/- 1.41 segments for the patients with typical injection locations at L2/3-L4/5. A mean dose of 6.25 +/- 0.18 mg per spinal segment was used. Side effects were not seen apart from occasional hypotension. The failures were not related to the anesthetic drug. The degree of muscle relaxation was for the majority of cases evaluated at 2 +, which was sufficient for the abdominal operations. The results are compared with the data obtained using bupivacaine-HC1; the advantages of bupivacaine-CO2 are described.
141例普通外科和泌尿外科手术患者采用0.5%布比卡因-二氧化碳溶液进行硬膜外麻醉（PDA）。观察到初始剂量在21 - 23毫升之间出现一个频率峰值。发现起效时间和潜伏期分别为2.99±1.40分钟和11.02±3.66分钟（最小时间单位0.5分钟）。有效持续时间为5.02±0.93小时。对于穿刺部位典型位于L2/3 - L4/5的患者，感觉平面平均达到T 6.06±1.41节段。每节段平均使用剂量为6.25±0.18毫克。除偶尔出现低血压外，未观察到副作用。麻醉失败与麻醉药物无关。大多数病例的肌肉松弛程度评估为2 +，这对腹部手术来说足够了。将结果与使用盐酸布比卡因获得的数据进行比较；描述了布比卡因-二氧化碳的优点。
