Mattila M A, Tuppurainen T, Larni H M, Gordin A, Salo H
Reg Anaesth. 1986 Oct;9(4):105-9.
Carbonated bupivacaine and bupivacaine hydrochloride were used for epidural anaesthesia in patients undergoing surgery of the lower extremities. Thirty patients received 20 ml 0.5% bupivacaine hydrochloride and 32 patients 20 ml 0.42% carbonated bupivacaine. Carbonated bupivacaine had a more rapid onset of action and spread of both sensory and motor blockade than its hydrochloride salt. The differences were statistically significant.
碳酸布比卡因和盐酸布比卡因用于下肢手术患者的硬膜外麻醉。30例患者接受20毫升0.5%盐酸布比卡因，32例患者接受20毫升0.42%碳酸布比卡因。碳酸布比卡因比其盐酸盐具有更快的起效时间以及感觉和运动阻滞扩散。差异具有统计学意义。
