Roles of cADPR and NAADP in pancreatic beta cell signaling.

Since the discovery of the pyridine nucleotide metabolites Ca mobilizing messengers cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), they have been demonstrated to function as Ca signaling messengers in a wide range of cell types. In this review, I will briefly summarize the roles of cADPR and NAADP in the physiological process of stimulus-secretion coupling in pancreatic β cells. I am also going to outline the current breadth of knowledge regarding intracellular Ca stores and Ca channels targeted by cADPR and NAADP, as well as the biogenesis of these Ca signaling messengers. I focused on receptor-mediated Ca signaling in mediating the effects of GLP-1 and insulin in pancreatic β cells. A better grasp in the roles of these signaling messengers will assist in our understanding of Ca signaling as well as pathophysiology.