Department of Physiology, The University of Hong Kong, Hong Kong, China.
Acta Biochim Biophys Sin (Shanghai). 2012 Sep;44(9):719-29. doi: 10.1093/abbs/gms044. Epub 2012 Jun 7.
Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are Ca(2+)-mobilizing nucleotides that were discovered in the late 1980s. Two decades of investigations have built up a considerable understanding about these two molecules that are related because both are derived from pyridine nucleotides and known to be generated by CD38/ADP-ribosyl cyclases. cADPR has been shown to target the ryanodine receptors in the endoplasmic reticulum whereas NAADP stimulates the two-pore channels in the endo-lysosomes. Accumulating results indicate that cADPR and NAADP are second messenger molecules mediating Ca(2+) signaling activated by a wide range of agonists. This article reviews what is known about these two molecules, especially regarding their signaling roles in the pancreatic cells.
环 ADP-核糖 (cADPR) 和烟碱酸腺嘌呤二核苷酸磷酸 (NAADP) 是两种钙动员核苷酸，于 20 世纪 80 年代末被发现。经过 20 年的研究，人们对这两种分子有了相当的了解，因为它们都源于吡啶核苷酸，并且已知是由 CD38/ADP-核糖基环化酶生成的。cADPR 已被证明靶向内质网中的 Ryanodine 受体，而 NAADP 则刺激内体溶酶体中的双孔通道。越来越多的结果表明，cADPR 和 NAADP 是第二信使分子，介导由广泛的激动剂激活的 Ca(2+)信号转导。本文综述了这两种分子的已知特性，特别是它们在胰腺细胞中的信号作用。
