Ruiz Guerrero Francisco, González Gómez Jana, Benito Gonzalez Pilar, García García Jesús, Berja Miguel Ana, Calcedo Giraldo Gabriel, García-Unzueta María Teresa, Gómez Del Barrio Andrés
Marqués de Valdecilla University Hospital, Eating Disorders Unit, Department of Psychiatry. Santander, Spain; IDIVAL, Santander, Spain.
Marqués de Valdecilla University Hospital, Eating Disorders Unit, Department of Psychiatry. Santander, Spain; IDIVAL, Santander, Spain.
Psychiatry Res. 2022 Apr;310:114449. doi: 10.1016/j.psychres.2022.114449. Epub 2022 Feb 13.
Growing interest exists in the association of the immune system and its role in the development and maintenance of eating disorders (ED). Current evidence suggests that serum cytokine levels seem to be elevated in females with anorexia nervosa (AN). However, less is known in bulimia nervosa (BN) and other specified feeding and eating disorders (OSFED), specially in males. We aimed to perform a case-control study in a sample of forty eight young patients (38 females and 10 males) with early diagnosis of AN, BN or OSFED and without any previous treatment, compared with twenty nine healthy controls (19 females and 10 males) matched by age, sex and socioeconomic status. We evaluated eating-related psychopathology and depressive symptoms and measured serum concentration of proinflammatory cytokines IL-1β, IL-6, and TNF-α and anti-inflammatory cytokine IL-10. Contrary to expectations, levels of IL-1β and IL-6 were significantly lower in ED patients, compared with healthy controls. Comparing the different groups of females, we found elevated levels of IL-10 among ED patients therefore supporting the idea of an immunosuppressive status in the early stages. This could indicate that early onset patients without any previous treatment could remain in a reward-dependent state with a lower immune response.
免疫系统及其在饮食失调（ED）的发生和维持中的作用之间的关联正受到越来越多的关注。目前的证据表明，神经性厌食症（AN）女性的血清细胞因子水平似乎升高。然而，关于神经性贪食症（BN）和其他特定的喂养及饮食失调（OSFED），尤其是男性患者，我们所知甚少。我们旨在对48名早期诊断为AN、BN或OSFED且未经任何治疗的年轻患者（38名女性和10名男性）进行病例对照研究，并与29名年龄、性别和社会经济地位相匹配的健康对照者（19名女性和10名男性）进行比较。我们评估了与饮食相关的精神病理学和抑郁症状，并测量了促炎细胞因子IL-1β、IL-6和TNF-α以及抗炎细胞因子IL-10的血清浓度。与预期相反，与健康对照者相比，ED患者的IL-1β和IL-6水平显著降低。比较不同组的女性，我们发现ED患者中IL-10水平升高，因此支持早期存在免疫抑制状态的观点。这可能表明，未经任何治疗的早期发病患者可能处于奖励依赖状态，免疫反应较低。
