Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University (LMU), Nussbaumstraße 7, 80336, Munich, Germany.
Schön Klinik Roseneck Affiliated With the Medical Faculty of the University of Munich (LMU), 83209, Prien, Germany.
Eat Weight Disord. 2021 Jun;26(5):1627-1637. doi: 10.1007/s40519-020-00960-1. Epub 2020 Aug 13.
To report on the mortality of DSM-IV eating disorders and predictors of premature death in males compared to females after inpatient treatment.
Crude mortality rate (CMR) and standardized mortality ratio (SMR) were computed for a large sample of males aged at treatment 16-61 years [N = 66 anorexia nervosa (AN), 52 bulimia nervosa (BN), 70 eating disorder not otherwise specified (ED-NOS)] and females aged 14-65 years (N = 2066 AN, 1880 BN, 1350 ED-NOS). In addition, a survival analysis and Cox regression analyses for identifying predictors of death were computed.
CMRs for males and females, respectively, were 15% and 5% in AN, 8% and 3% in BN, and 4% and 3% in ED-NOS. Compared to the general population, mortality was elevated in males with AN (SMR = 4.93) and in all female diagnostic groups (AN, BN, ED-NOS). No significant sex differences for SMR emerged in any diagnostic group. Compared to females with AN or BN, males with AN or BN showed a shorter survival time after onset (survival analysis). Being male, and having AN, increased the risk of premature death.
Mortality in inpatients with eating disorder is high, especially in AN. Males appear to have about the same outcome in terms of mortality as females with AN, BN, and ED-NOS. However, long-term survival was shorter in males with AN or BN compared to females. The need for intensive treatment in both males and females with an eating disorder remains an important issue.
Level III, case-control analytic study.
报告 DSM-IV 饮食障碍患者的死亡率，并比较男女患者住院治疗后过早死亡的预测因素。
对年龄在 16-61 岁的大量男性样本（包括 66 名神经性厌食症（AN）患者、52 名神经性贪食症（BN）患者和 70 名未特定饮食障碍（ED-NOS）患者）和年龄在 14-65 岁的女性样本（包括 2066 名 AN 患者、1880 名 BN 患者和 1350 名 ED-NOS 患者）进行了粗死亡率（CMR）和标准化死亡率比（SMR）的计算。此外，还进行了生存分析和 Cox 回归分析，以确定死亡的预测因素。
男性和女性的 CMR 分别为 AN 中的 15%和 5%、BN 中的 8%和 3%，以及 ED-NOS 中的 4%和 3%。与一般人群相比，患有 AN 的男性（SMR=4.93）和所有女性诊断组（AN、BN 和 ED-NOS）的死亡率均升高。在任何诊断组中，SMR 均无显著的性别差异。与患有 AN 或 BN 的女性相比，患有 AN 或 BN 的男性在发病后生存时间更短（生存分析）。男性和患有 AN 会增加过早死亡的风险。
患有饮食障碍的住院患者死亡率较高，尤其是 AN。在死亡率方面，男性与患有 AN、BN 和 ED-NOS 的女性似乎具有相同的预后。然而，与女性相比，患有 AN 或 BN 的男性的长期生存时间更短。男性和女性患有饮食障碍均需要强化治疗，这仍然是一个重要问题。
III 级，病例对照分析研究。
