Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Victoria, Australia.
Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Victoria, Australia; Department of Rehabilitation Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.
Mech Ageing Dev. 2022 Apr;203:111648. doi: 10.1016/j.mad.2022.111648. Epub 2022 Feb 24.
A higher number of laboratory measurements is associated with mortality in patients admitted to hospital, but is not part of the frailty index based on laboratory tests (FILab). This study aimed to modify the FI-Lab (mFI-Lab) by accounting for the number of laboratory measurements and compare its validity to predict institutionalization and mortality at three-month post-discharge with the clinical frailty scale (CFS) in geriatric rehabilitation inpatients. In 1819 patients (median age 83.3 [77.6-88.3], 56.6% female), a higher FI-Lab was not associated with institutionalization but a higher risk of mortality. A higher mFI-Lab was associated with lower odds of institutionalization but a higher risk of mortality. A higher CFS was associated with institutionalization and higher mortality. The Akaike information criterion value was lowest for the CFS, followed by the mFI-Lab and the FI-Lab. The CFS is better than the mFI-Lab predicting short-term adverse outcomes in geriatric rehabilitation inpatients. When using laboratory data to estimate frailty, the mFI-Lab rather than the FI-Lab should be used.
实验室检测指标数量与住院患者的死亡率相关，但并不属于基于实验室检测的衰弱指数（FILab）的一部分。本研究旨在通过纳入实验室检测指标数量来修正 FILab（mFI-Lab），并比较其在预测老年康复住院患者出院后 3 个月内的失能和死亡方面的有效性，与临床衰弱量表（CFS）进行比较。在 1819 名患者中（中位数年龄 83.3[77.6-88.3]，56.6%为女性），较高的 FILab 与失能无关，但与死亡率升高相关。较高的 mFI-Lab 与较低的失能风险相关，但与较高的死亡率相关。较高的 CFS 与失能和较高的死亡率相关。Akaike 信息准则值最低的是 CFS，其次是 mFI-Lab 和 FILab。在预测老年康复住院患者短期不良结局方面，CFS 优于 mFI-Lab。当使用实验室数据来估计衰弱时，应使用 mFI-Lab 而不是 FILab。
