哺乳动物过氧化物酶体增殖物激活受体（PXDN）：从生理学到病理学。
Mammalian peroxidasin (PXDN): From physiology to pathology.
机构信息
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha, China.
出版信息
Free Radic Biol Med. 2022 Mar;182:100-107. doi: 10.1016/j.freeradbiomed.2022.02.026. Epub 2022 Feb 24.
Abstract
Heme-containing peroxidases catalyze the oxidation of a variety of substrates by consuming hydrogen peroxide (HO), and play diversified roles in physiology and pathology including innate immunity, the synthesis of thyroid hormone and the extracellular matrix, as well as the pathogenesis of several inflammatory diseases. Peroxidasin (PXDN), also known as Vascular Peroxidase-1 (VPO1), is a newly identified peroxidase and expresses in multiple cells and tissues including cardiovascular system and the lung. Recent studies imply its roles in the innate immunity, cardiovascular physiology and diseases, and extracellular matrix formation. Studies on the role of PXDN in human diseases are entering a new and exciting stage, and this review provides the insights into this emerging field of PXDN.
摘要
含血红素的过氧化物酶通过消耗过氧化氢（HO）来催化各种底物的氧化，在包括先天免疫、甲状腺激素和细胞外基质的合成以及几种炎症性疾病的发病机制在内的生理学和病理学中发挥多样化的作用。过氧化物酶体（PXDN）也称为血管过氧化物酶-1（VPO1），是一种新鉴定的过氧化物酶，在包括心血管系统和肺部在内的多种细胞和组织中表达。最近的研究表明其在先天免疫、心血管生理学和疾病以及细胞外基质形成中的作用。关于 PXDN 在人类疾病中的作用的研究正在进入一个新的令人兴奋的阶段，本综述提供了对 PXDN 这一新兴领域的深入了解。
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