Laboratório de Radioisótopos, Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Campus Pampulha, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Laboratório de Farmacologia da Dor e Inflamação, Universidade Federal de São João del-Rei (UFSJ) - Campus Centro Oeste Dona Lindu, Divinópolis, Minas Gerais, Brazil.
J Mycol Med. 2022 Aug;32(3):101255. doi: 10.1016/j.mycmed.2022.101255. Epub 2022 Feb 15.
Vulvovaginal candidosis (VVC) is one of the most frequent causes of gynecological consultations. Therefore, the development of new antifungal therapies against VVC is relevant. In this context, the leaves of Fridericia chica (Bonpl.) L. G. Lohmann are considered a therapeutic alternative since they are traditionally used in VVC therapy. However, no scientific evidence has supported this use against fungal vaginal infections. Then, we aimed to characterize the antifungal effect of a hydroethanolic extract of F. chica leaves (HEFc) and evaluate the therapeutic potential of this extract in a VVC model. HEFc inhibited the growth of C. albicans (256-1,204 µg/mL) and C. krusei (512 µg/mL) in vitro. HEFc inhibited yeast-to-hypha transition in C. albicans and has a low ability to induce resistance in this species. Intravaginal use of the HEFc at 50 mg/mL causes mycological cure in animals with VVC after 6 days of treatment, similar to the effect observed for the commercial antifungal nystatin. These results support the traditional use of F. chica leaves as a topical therapeutic option to treat VVC.
外阴阴道念珠菌病（VVC）是妇科咨询最常见的原因之一。因此，开发针对 VVC 的新抗真菌疗法具有重要意义。在这种情况下，Fridericia chica（Bonpl。）L. G. Lohmann 的叶子被认为是一种治疗选择，因为它们传统上用于 VVC 治疗。然而，没有科学证据支持这种用于治疗真菌性阴道感染的用途。然后，我们旨在表征 Fridericia chica 叶的水醇提取物（HEFc）的抗真菌作用，并评估该提取物在 VVC 模型中的治疗潜力。HEFc 在体外抑制白色念珠菌（256-1,204 µg/mL）和克柔念珠菌（512 µg/mL）的生长。HEFc 抑制白色念珠菌的酵母到菌丝的转变，并且在该物种中诱导耐药性的能力较低。在患有 VVC 的动物中，阴道内使用 50 mg/mL 的 HEFc 在 6 天的治疗后可引起真菌学治愈，与商业抗真菌药物制霉菌素的效果相似。这些结果支持将 Fridericia chica 叶作为局部治疗选择用于治疗 VVC 的传统用途。
