Gustave Roussy Comprehensive Cancer Institute, Villejuif, France; Université Paris Saclay, Faculty of Medicine, Le Kremlin-Bicêtre, France; INSERM U1015, Paris, France; Equipe labellisée par la Ligue contre le Cancer, Villejuif, France; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) BIOTHERIS, Villejuif, France.
Equipe labellisée par la Ligue contre le Cancer, Université de Paris, Sorbonne Université, Institut Universitaire de France, Inserm U1138, Centre de Recherche des Cordeliers, Paris, France; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
Curr Opin Immunol. 2022 Apr;75:102171. doi: 10.1016/j.coi.2022.102171. Epub 2022 Feb 24.
The composition of the gut microbiota has a major impact on anticancer immunosurveillance. This effect is in part determined by systemic effects of bacterial or fungal metabolites, as well as by microbial ligands of pattern recognition receptors that modulate adjuvant signals and hence determine the general immune tonus. In addition, microbial antigens can elicit specific T lymphocyte responses that are cross-reactive with respect to tumor-associated antigens, hence inducing specific antitumor immune responses. Here, we discuss current evidence in favor of such cross-reactive anticancer/antimicrobial T cell response and delineate a methodology to demonstrate their actual importance for the immune control of malignant cells.
肠道微生物组的组成对癌症的免疫监视有重大影响。这种影响部分是由细菌或真菌代谢物的全身作用以及模式识别受体的微生物配体决定的，这些配体调节佐剂信号，从而决定一般的免疫张力。此外，微生物抗原可以引发与肿瘤相关抗原具有交叉反应性的特异性 T 淋巴细胞反应，从而诱导针对肿瘤的特异性免疫反应。在这里，我们讨论了支持这种交叉反应性抗癌/抗微生物 T 细胞反应的现有证据，并描述了一种方法来证明它们对免疫控制恶性细胞的实际重要性。
