Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Neuroscience section, University of Salerno, Baronissi, Italy.
The University of Maryland School of Medicine, Baltimore, MD, USA.
J Neurol Sci. 2022 Apr 15;435:120200. doi: 10.1016/j.jns.2022.120200. Epub 2022 Feb 19.
Although tremor is deemed to be the commonest movement disorder, in adults the differential diagnosis usually boils down to whether the patient has Essential Tremor or Parkinson's Disease, which has likely led to an overdiagnosis of these conditions; yet, many important rare syndromes should be considered in the differential diagnosis of patients with tremor. The aim of this review is to focus on rare forms of tremor, also in view of the new tremor classification, as well as on tremor occurring in other neurological disorders to aid their recognition. Some of the conditions reviewed here are treatable and therefore should not be missed. This review includes orthostatic tremor, focal and task-specific tremors, Holmes tremor, palatal and oculopalatal tremor, cortical tremor, some genetic forms of tremor including fragile X-associated tremor/ataxia syndrome as well as tremor associated with neuromuscular disorders, multiple sclerosis and Wilson's disease, providing an array of demonstrative videos. The recognition of these disorders should aid the physician to make a correct diagnosis and guide a prompt intervention. This article is part of the Special Issue "Tremor" edited by Daniel D. Truong, Mark Hallett, and Aasef Shaikh.
虽然震颤被认为是最常见的运动障碍,但在成年人中,鉴别诊断通常归结为患者是患有特发性震颤还是帕金森病,这可能导致这些疾病的过度诊断;然而,许多重要的罕见综合征也应在震颤患者的鉴别诊断中考虑。本文的目的是重点介绍罕见的震颤形式,也考虑到新的震颤分类,以及在其他神经系统疾病中发生的震颤,以帮助识别它们。本文回顾的一些病症是可治疗的,因此不应被忽视。本文包括直立性震颤、局灶性和任务特异性震颤、霍姆斯震颤、腭肌和眼-腭震颤、皮质震颤、包括脆性 X 相关震颤/共济失调综合征在内的一些遗传性震颤形式,以及与神经肌肉疾病、多发性硬化症和威尔逊病相关的震颤,提供了一系列有代表性的视频。识别这些疾病应有助于医生做出正确的诊断并指导及时干预。本文是由 Daniel D. Truong、Mark Hallett 和 Aasef Shaikh 编辑的特刊“Tremor”的一部分。