不同多囊卵巢综合征表型患者健康相关生活质量的比较：一项横断面研究。

Comparison of health-related quality of life in different polycystic ovary syndrome phenotypes: A cross-sectional study.

机构信息

From the Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2022 Apr;271:189-194. doi: 10.1016/j.ejogrb.2022.02.014. Epub 2022 Feb 17.

DOI:10.1016/j.ejogrb.2022.02.014

PMID:35220174

Abstract

OBJECTIVE

The goal of this research was to evaluate the Health-Related Quality of Life (HRQoL) of Chinese women with varying phenotypes of Polycystic Ovary Syndrome (PCOS) and related factors in order to guide clinical treatment.

METHODS

We employed a cross-sectional design that included 221 women with an initial diagnosis of PCOS at the Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital. All subjects were stratified, according to the Rotterdam criteria, into three sub-cohorts: phenotype A (n = 100), phenotype B (n = 60), and phenotype D (n = 61). All patients completed the Modified Polycystic Ovary Syndrome Health Related Quality of Life Questionnaire (MPCOSQ).

RESULTS

The three PCOS phenotypes showed no obvious differences in terms of the overall mean MPCOSQ score. However, patients in phenotype D exhibited markedly elevated weight, hirsutism, and acne scores, as compared to phenotypes A and B (p＜0.05). Among all phenotypes, A and B exhibited the worst weight-related HRQoL (3.58 ± 1.89, 3.42 ± 1.99). In contrast, phenotype D displayed the worst emotional disturbance (3.74 ± 1.25), followed by infertility (3.86 ± 1.99). According to the multiple linear regression analysis, worse HRQoL in Phenotypes A and B was significantly associated with excess body weight (Beta = -0.387,-0.626,p＜0.001), hirsutism (Beta = -0.309,-0.269p＜0.01), and abnormal menstruation (Beta = -0.283,-0.304,p＜0.01). In contrast, there was no marked association between HRQoL and hirsutism in Phenotype D.

CONCLUSION

Personalized treatment and management must be provided, based on various factors that influence HRQoL among the three PCOS phenotypes. Based on our analysis, the interventions that greatly improve HRQoL of PCOS patients are significant weight loss, combined with anti-androgen administration for phenotypes A and B, and fertility enhancement, combined with menstruation regulation, for phenotype D.

摘要

目的

本研究旨在评估不同表型多囊卵巢综合征（PCOS）中国女性的健康相关生活质量（HRQoL）及其相关因素，以便为临床治疗提供指导。

方法

我们采用了横断面设计，纳入了 221 名在天津医科大学总医院妇产科初诊为 PCOS 的女性。根据鹿特丹标准，所有患者均分为三个亚组：表型 A（n=100）、表型 B（n=60）和表型 D（n=61）。所有患者均完成了多囊卵巢综合征健康相关生活质量量表修订版（MPCOSQ）的评估。

结果

三种 PCOS 表型的 MPCOSQ 总分无明显差异。然而，表型 D 的患者体重、多毛症和痤疮评分明显高于表型 A 和表型 B（p＜0.05）。在所有表型中，A 和 B 型的体重相关 HRQoL 最差（3.58±1.89，3.42±1.99）。相反，表型 D 表现出最严重的情绪障碍（3.74±1.25），其次是不孕（3.86±1.99）。根据多元线性回归分析，表型 A 和 B 的 HRQoL 较差与超重（Beta=-0.387，-0.626，p＜0.001）、多毛症（Beta=-0.309，-0.269，p＜0.01）和月经异常（Beta=-0.283，-0.304，p＜0.01）显著相关。相比之下，表型 D 的 HRQoL 与多毛症之间无显著关联。