Urology Unit, Cannizzaro Hospital, Catania, Italy
Urology Unit, Cannizzaro Hospital, Catania, Italy.
Anticancer Res. 2022 Mar;42(3):1495-1498. doi: 10.21873/anticanres.15621.
BACKGROUND/AIM: To evaluate the accuracy of 68Gallium prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) vs. CT combined with bone scan in the clinical staging of high-risk prostate cancer (PCa).
From January 2020 to October 2021, 30 patients underwent clinical staging according to 68Ga-PSMA PET/TC, lung-abdominal CT and Technetium-99m bone scan.
68Ga-PSMA PET/CT demonstrated a better accuracy in comparison with CT plus bone scan in the diagnosis of node metastases at definitive histology (76.9% vs. 46.1%; p=0.001).
The 68Ga-PSMA PET/CT was more accurate than CT and bone scan in the staging of high-risk PCa, leading to a change in the therapeutic strategy in 10% of the cases.
背景/目的：评估 68 镓前列腺特异性膜抗原（PSMA）正电子发射断层扫描/计算机断层扫描（PET/CT）与 CT 联合骨扫描在高危前列腺癌（PCa）临床分期中的准确性。
2020 年 1 月至 2021 年 10 月，30 例患者根据 68Ga-PSMA PET/TC、肺腹 CT 和锝 99m 骨扫描进行临床分期。
68Ga-PSMA PET/CT 在明确组织学诊断时对淋巴结转移的诊断准确性优于 CT 加骨扫描（76.9% vs. 46.1%；p=0.001）。
68Ga-PSMA PET/CT 在高危 PCa 的分期中比 CT 和骨扫描更准确，导致 10%的病例治疗策略发生改变。
