Does MURCS association represent an actual nonrandom complex of malformations?

The MURCS association was first suggested by Duncan in 1979 as a distinctive nonrandom association of congenital anomalies involving the Mullerian duct, the kidneys and the cervicothoracic spine. Two personal cases, highly resembling Duncan's description, are reported. In our opinion, they seem to support somehow the hypothesis that MURCS association should be considered as an autonomous pathological entity. The great phenotypical variability and the still unknown etiopathogenetic mechanism are particularly stressed.