Institute of Inflammation and Ageing, MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK.
Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.
Adv Exp Med Biol. 2022;1363:35-70. doi: 10.1007/978-3-030-92034-0_4.
The last decade has seen an enormous increase in long non-coding RNA (lncRNA) research within rheumatology. LncRNAs are arbitrarily classed as non-protein encoding RNA transcripts that exceed 200 nucleotides in length. These transcripts have tissue and cell specific patterns of expression and are implicated in a variety of biological processes. Unsurprisingly, numerous lncRNAs are dysregulated in rheumatoid conditions, correlating with disease activity and cited as potential biomarkers and targets for therapeutic intervention. In this chapter, following an introduction into each condition, we discuss the lncRNAs involved in rheumatoid arthritis, osteoarthritis and systemic lupus erythematosus. These inflammatory joint conditions share several inflammatory signalling pathways and therefore not surprisingly many commonly dysregulated lncRNAs are shared across these conditions. In the interest of translational research only those lncRNAs which are strongly conserved have been addressed. The lncRNAs discussed here have diverse roles in regulating inflammation, proliferation, migration, invasion and apoptosis. Understanding the molecular basis of lncRNA function in rheumatology will be crucial in fully determining the inflammatory mechanisms that drive these conditions.
过去十年，风湿病学领域的长链非编码 RNA（lncRNA）研究取得了巨大进展。lncRNA 被任意归类为非蛋白编码 RNA 转录本，其长度超过 200 个核苷酸。这些转录本具有组织和细胞特异性表达模式，并涉及多种生物学过程。毫不奇怪，许多 lncRNA 在类风湿条件下失调，与疾病活动相关，并被认为是潜在的生物标志物和治疗干预靶点。在本章中，在对每种疾病进行介绍后，我们讨论了与类风湿关节炎、骨关节炎和系统性红斑狼疮相关的 lncRNA。这些炎症性关节疾病共享几种炎症信号通路，因此毫不奇怪，许多常见失调的 lncRNA 在这些疾病中是共有的。为了转化研究的目的，我们只讨论了那些具有强烈保守性的 lncRNA。这里讨论的 lncRNA 在调节炎症、增殖、迁移、侵袭和凋亡方面具有多种作用。了解 lncRNA 在风湿病学中的分子基础对于充分确定驱动这些疾病的炎症机制至关重要。
