长链非编码 RNA 在系统性红斑狼疮中的新兴作用。
Emerging role of lncRNAs in systemic lupus erythematosus.
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, Anhui, China.
Department of Rheumatology and Immunology, Anhui Provincial Hospital, 17 Lujiang Road, Hefei, Anhui, China.
出版信息
Biomed Pharmacother. 2018 Oct;106:584-592. doi: 10.1016/j.biopha.2018.06.175. Epub 2018 Jul 11.
Long non-coding RNAs (lncRNAs), defined as ≥200 base pairs in length but have little translation potential, play a key role in imprinting control, immune cell differentiation, apoptosis and immune responses. Recently, many potential lncRNAs have been revealed to contribute to a new layer of molecular regulation of systemic lupus erythematosus (SLE). Immune-related functional lncRNAs may serve as novel therapeutic targets and disease biomarkers to provide potential support for clinic treatment in this disease. In this review, we will briefly introduce the identification, biogenesis and functions of lncRNAs, and summarize recent advance in the role of lncRNAs in SLE.
长非编码 RNA（lncRNA），定义为长度≥200 个碱基但几乎没有翻译潜能，在印迹控制、免疫细胞分化、凋亡和免疫反应中发挥关键作用。最近，许多潜在的 lncRNA 被揭示有助于全身性红斑狼疮（SLE）的分子调控的一个新层面。免疫相关功能 lncRNA 可能作为新的治疗靶点和疾病生物标志物，为该疾病的临床治疗提供潜在支持。在这篇综述中，我们将简要介绍 lncRNA 的鉴定、生物发生和功能，并总结 lncRNA 在 SLE 中的作用的最新进展。
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