Kumar Vijay, Prasher Indu Bhushan
Mycology and Plant Pathology Laboratory, Department of Botany, Panjab University, Chandigarh, India.
Nat Prod Res. 2022 Dec;36(23):6064-6068. doi: 10.1080/14786419.2022.2043855. Epub 2022 Feb 27.
The present study evaluated the antibacterial potential of endophytic fungi isolated from L. and identified bioactive compounds responsible for their antimicrobial activity. A total of twenty-five endophytic fungi were preliminarily screened for their antibacterial activity against human pathogenic bacteria, i.e., and by dual culture assay. The strains having antibacterial activity were selected and crude extracts were prepared from them. The crude extracts were screened for antibacterial activity by agar well diffusion assay. The ethyl acetate extract of showed the highest activity against selected human pathogenic bacteria, with a zone of inhibition ranging from 15 to 29 mm. The Gas chromatography-Mass spectrometry (GC-MS) analysis of the ethyl acetate extract of showed the presence of 40 compounds with predominance of Dodecane (8.87%), Ethyl 2-thiopheneacetate (4.12%), Tetradecane (13.86%), Hexadecane (12.05%), Octadecane (6.67%), Benzaldehyde, 4-(1-methylethyl)- (10.83%), Griseofulvin (3.31%).
本研究评估了从[植物名称未给出]分离出的内生真菌的抗菌潜力，并鉴定了具有抗菌活性的生物活性化合物。通过双重培养试验，对总共25种内生真菌针对人类病原菌（即[病原菌名称未给出]和[病原菌名称未给出]）的抗菌活性进行了初步筛选。选择具有抗菌活性的菌株并从中制备粗提物。通过琼脂孔扩散试验对粗提物的抗菌活性进行筛选。[菌株名称未给出]的乙酸乙酯提取物对选定的人类病原菌显示出最高活性，抑菌圈范围为15至29毫米。[菌株名称未给出]的乙酸乙酯提取物的气相色谱-质谱（GC-MS）分析表明存在40种化合物，其中以十二烷（8.87%）、2-噻吩乙酸乙酯（4.12%）、十四烷（13.86%）、十六烷（12.05%）、十八烷（6.67%）、4-(1-甲基乙基)苯甲醛（10.83%）、灰黄霉素（3.31%）为主。
