阿奇霉素对新冠病毒感染儿童心室复极化的影响。
Effects of azithromycin on ventricular repolarization in children with COVID-19.
作者信息
Sunkak Suleyman, Argun Mustafa, Celik Binnaz, Tasci Onur, Ozturk Agah Bahadir, Inan Dogan Bahadir, Dogan Murat
机构信息
Kayseri City Hospital, Kayseri, Turkey.
Department of Pediatrics, Pediatric Cardiology Division, Kayseri Education and Research City Hospital, Kayseri, Turkey.
出版信息
Rev Port Cardiol. 2022 Jul;41(7):551-556. doi: 10.1016/j.repc.2021.04.008. Epub 2022 Feb 21.
INTRODUCTION
Azithromycin is used to treat pediatric COVID-19 patients. It can also prolong the QT interval in adults. This study assessed the effects of azithromycin on ventricular repolarization in children with COVID-19.
METHOD
The study prospectively enrolled children with COVID-19 who received azithromycin between July and August 2020. An electrocardiogram was performed before, one, three, and five days post-treatment. Using ImageJ®, the following parameters were measured: QT max, QT min, Tp-e max, and Tp-e min. The parameters QTc max, QTc min, Tp-ec max, Tp-ec min, QTcd, Tp-ecd, and the QTc/Tp-ec ratio were calculated using Bazett's formula.
RESULTS
The study included 105 pediatric patients (mean age 9.8±5.3 years). The pretreatment heart rate was higher than after treatment (before 92 [79-108]/min vs. Day 1 82 [69-108)]/min vs. Day 3 80 [68-92.2]/min vs. Day 5 81 [70-92]/min; p=0.05).
CONCLUSION
Azithromycin does not affect the ventricular repolarization parameters on ECG in pediatric COVID-19 cases.
引言
阿奇霉素用于治疗儿童新冠病毒肺炎患者。它在成人中还可延长QT间期。本研究评估了阿奇霉素对新冠病毒肺炎患儿心室复极的影响。
方法
本研究前瞻性纳入了2020年7月至8月期间接受阿奇霉素治疗的新冠病毒肺炎患儿。在治疗前、治疗后1天、3天和5天进行心电图检查。使用ImageJ®测量以下参数：QT最大值、QT最小值、Tp-e最大值和Tp-e最小值。使用Bazett公式计算QTc最大值、QTc最小值、Tp-ec最大值、Tp-ec最小值、QTcd、Tp-ecd以及QTc/Tp-ec比值。
结果
该研究纳入了105例儿科患者（平均年龄9.8±5.3岁）。治疗前心率高于治疗后（治疗前92[79 - 108]/分钟 vs. 第1天82[69 - 108]/分钟 vs.第3天80[68 - 92.2]/分钟 vs.第5天81[70 - 92]/分钟；p = 0.05）。
结论
在儿童新冠病毒肺炎病例中，阿奇霉素不影响心电图上的心室复极参数。
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