比较胸部 CT 和 RT-PCR 诊断的 COVID-19 患者的心室复极参数。
Comparison of ventricular repolarization parameters of Covid-19 patients diagnosed with chest CT and RT-PCR.
机构信息
Cardiology Department, Başakşehir Çam and Sakura City Hospital, İstanbul, Turkey.
Cardiology Department, Tatvan State Hospital, Bitlis, Turkey.
出版信息
Acta Cardiol. 2021 Nov;76(9):1013-1018. doi: 10.1080/00015385.2021.1950366. Epub 2021 Jul 13.
BACKGROUND AND OBJECTIVES
The aim of the comparison is to evaluate the marker of ventricular repolarization parameters such as QT, QTc, cQT, Tp-e, Tp-e/QT, Tp-e/QTc, Tp-e/JT and Tp-e/JTc ratios and the risk of ventricular arrhtythmias in patients with newly diagnosed Covid-19.
METHODS
The study included 2 separate groups. The first one consisted of 96 positive reverse transcriptase polymerase chain reaction (RT-PCR) Covid-19 patients and the second one of 106 patients with negative PCR but positive chest computed tomography (CT) findings consistent with Covid-19. We measured QTmax, QTmin, QRS, JT and Tp-e intervals and estimated Tp-e/QT max, Tp- e/QTc max, Tp-e/JT and Tp-e/JTc rates and QTc max, QTc min, cQTd and JTc intervals.
RESULTS
QT max, QT min, JT, cQTd, Tp-e, Tp-e/QT max, Tp-e/QTc max, Tp-e/JT, Tp-e/JTc values were significantly higher in RT-PCR Covid-19 patient group.
CONCLUSION
Positive RT-PCR Covid-19 patients should be followed more closely, in terms of high ventricular repolarization parameters and preventing ventricular arrhythmias that may develop due to this.
背景与目的
本研究旨在比较评估心室复极参数标志物，如 QT、QTc、cQT、Tp-e、Tp-e/QT、Tp-e/QTc、Tp-e/JT 和 Tp-e/JTc 比值，以及新诊断的 COVID-19 患者发生室性心律失常的风险。
方法
该研究纳入了两个独立的组。第一组包括 96 例 RT-PCR 新冠病毒检测阳性的 COVID-19 患者，第二组包括 106 例 RT-PCR 阴性但胸部 CT 阳性符合 COVID-19 的患者。我们测量了 QTmax、QTmin、QRS、JT 和 Tp-e 间期，并估计了 Tp-e/QT max、Tp-e/QTc max、Tp-e/JT 和 Tp-e/JTc 比值以及 QTc max、QTc min、cQTd 和 JTc 间期。
结果
RT-PCR 新冠病毒检测阳性的 COVID-19 患者组的 QTmax、QTmin、JT、cQTd、Tp-e、Tp-e/QT max、Tp-e/QTc max、Tp-e/JT、Tp-e/JTc 值显著升高。
结论
阳性 RT-PCR COVID-19 患者应更密切地随访，以监测可能因这些参数升高而导致的室性心律失常。
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