Nakagawa Minto, Hayashi Shuji, Matsuo Saori, Yamazaki Masaki, Kato Atsuhiko
Translational Research Division, Chugai Pharmaceutical Co., Ltd., 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan.
J Toxicol Pathol. 2022 Jan;35(1):113-116. doi: 10.1293/tox.2021-0054. Epub 2021 Nov 15.
Lipomatosis of lymph nodes is defined as the replacement of the lymphatic parenchyma by adipose tissue which grows in the node from the hilus toward the cortical zone. In humans, it is considered as part of the normal aging process and is common in obese patients, but there are no reports in non-human primates. In this report, we describe the first case of lymph node lipomatosis in the bilateral axillary lymph nodes of a young adult cynomolgus monkey. Macroscopically, there were no apparent abnormalities in the axillary lymph nodes on either side, and their volumes were unchanged. At the cut surface, pale yellow fat-like tissue was observed in the medullary area. Histopathologically, well differentiated adipocytes replaced a large part of the lymphatic parenchyma in the area from the hilus to the medulla without any malignant findings. Based on these findings, the patient was diagnosed with lipomatosis of the lymph nodes.
淋巴结脂肪瘤病的定义是脂肪组织取代淋巴实质，脂肪组织在淋巴结内从门部向皮质区生长。在人类中，它被认为是正常衰老过程的一部分，在肥胖患者中很常见，但在非人灵长类动物中尚无相关报道。在本报告中，我们描述了一只年轻成年食蟹猴双侧腋窝淋巴结脂肪瘤病的首例病例。宏观上，双侧腋窝淋巴结无明显异常，体积未变。在切面处，髓质区域可见淡黄色脂肪样组织。组织病理学检查显示，从门部到髓质区域，分化良好的脂肪细胞取代了大部分淋巴实质，未发现任何恶性病变。基于这些发现，该病例被诊断为淋巴结脂肪瘤病。
