Laboratory of the Lymph System Physiology, Institute of Human and Animal Physiology, Ministry of Education and Science of the Republic of Kazakhstan, Almaty, Kazakhstan.
Bull Exp Biol Med. 2021 Jan;170(3):283-287. doi: 10.1007/s10517-021-05052-3. Epub 2021 Jan 16.
Adrenergic innervation in the tissue of the cervical, mesenteric, and popliteal lymph nodes in rats of different age groups (from 2-45 days to 24 months) was studied using the specific fluorescence-microscopic imaging of catecholamines. Adrenergic innervation in the lymph nodes of rats is present from the first days of life, but it develops and complicates during postnatal ontogeny and is fully formed by thedays 20-30 of life. By the age of one month, adrenergic innervation represents a well-formed apparatus in all parts of the node, i.e. in the capsule, trabeculae, and cortical and medullary substance. These are brightly fluorescent nerve fibers that form plexuses with regularly located multiple varicosities. In senile animals, the density and number of plexuses in all parts of the lymph node are preserved, but the brightness of plexuses decreases, plexus fibers become discontinuous, varicosities become less frequent or disappear. These changes are seen in lymph nodes from different body regions.
采用儿茶酚胺的特异性荧光显微镜成像技术，研究了不同年龄组（2-45 天至 24 个月）大鼠颈、肠系膜和腘淋巴结组织中的肾上腺素能神经支配。从出生的第一天起，大鼠淋巴结中就存在肾上腺素能神经支配，但它在出生后发育和复杂化，并在生命的第 20-30 天完全形成。到一个月大时，肾上腺素能神经支配在淋巴结的所有部位都代表一个形成良好的器官，即包膜、小梁和皮质及髓质。这些是明亮荧光的神经纤维，它们形成具有定期定位的多个膨体的丛。在老年动物中，淋巴结所有部位的丛密度和数量都保持不变，但丛的亮度降低，丛纤维变得不连续，膨体变得不那么频繁或消失。这些变化可见于来自不同身体区域的淋巴结。
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