Salmi H A, Lehtomäki K, Kylmämaa T
Drugs Exp Clin Res. 1986;12(4):349-53.
Brodimoprim and doxycycline monotherapies were compared in the treatment of acute respiratory tract infections in a randomized double-blind trial. The brodimoprim dose was 400 mg as a single loading dose followed by 200 mg for 10 days at bedtime. The corresponding doses of doxycycline were 200 and 100 mg respectively. Both treatment groups consisted of 30 patients. In the brodimoprim group, 23 patients recovered completely, five improved and two did not respond. In the doxycycline group, 26 patients recovered completely, three improved and one was considered a failure. Only one patient in the brodimoprim group had moderate diarrhoea.
在一项随机双盲试验中，对溴莫普明和多西环素单药疗法治疗急性呼吸道感染进行了比较。溴莫普明剂量为单次负荷剂量400mg，随后在睡前服用200mg，共10天。多西环素的相应剂量分别为200mg和100mg。两个治疗组均由30名患者组成。在溴莫普明组中，23例患者完全康复，5例病情改善，2例无反应。在多西环素组中，26例患者完全康复，3例病情改善，1例被视为治疗失败。溴莫普明组只有1例患者出现中度腹泻。
