Cauwenbergh G
Drugs Exp Clin Res. 1986;12(5):419-27.
During the last three years, several studies have investigated the potential of ketoconazole for antifungal prophylaxis in immunocompromised patients. Ketoconazole 200 mg o.d. seems to have some effect, but this daily dose is considered too low. Studies using higher doses suggest an increased prophylactic effect with 400 mg and adequate prophylaxis with 600 mg ketoconazole daily. When compared with other antifungals, ketoconazole seems to be superior to nystatin and as effective as amphotericin B (500 mg t.i.d.).
在过去三年中，多项研究探讨了酮康唑在免疫功能低下患者中进行抗真菌预防的潜力。酮康唑每日200毫克似乎有一定效果，但该日剂量被认为过低。使用更高剂量的研究表明，每日400毫克时预防效果增强，每日600毫克酮康唑时预防效果良好。与其他抗真菌药物相比，酮康唑似乎优于制霉菌素，且与两性霉素B（每日三次，每次500毫克）效果相当。
