Calabrese Edward J
Department of Environmental Health Sciences, University of Massachusetts, Amherst, MA, USA.
Dose Response. 2022 Feb 23;20(1):15593258211068625. doi: 10.1177/15593258211068625. eCollection 2022 Jan-Mar.
Hormetic-biphasic dose response relationships are reported herein for human endothelial progenitor cells involving estradiol, nicotine, the anti-diabetic agent pioglitazone, resveratrol, and progesterone. In general, these studies demonstrate the capacity of these agents to enhance EPC proliferation and angiogenesis functional applications, having a focus on repairing endothelial tissue damage due to acute injury (e.g., stroke), as well as damage from chronic conditions (e.g., atherosclerosis) and normal aging processes.
本文报道了涉及雌二醇、尼古丁、抗糖尿病药物吡格列酮、白藜芦醇和孕酮的人类内皮祖细胞的兴奋效应双相剂量反应关系。总体而言，这些研究证明了这些药物增强内皮祖细胞增殖和血管生成功能应用的能力，重点在于修复急性损伤（如中风）、慢性疾病（如动脉粥样硬化）和正常衰老过程导致的内皮组织损伤。
Zotero 插件
