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诱导多能干细胞与兴奋效应。

Induced Pluripotent Stem Cells and Hormesis.

作者信息

Calabrese Edward J

机构信息

Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA.

出版信息

Dose Response. 2022 Mar 3;20(1):15593258221075504. doi: 10.1177/15593258221075504. eCollection 2022 Jan-Mar.

DOI:10.1177/15593258221075504
PMID:35283697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8905229/
Abstract

This paper represents the first assessment of agent-induced hormetic dose responses in induced pluripotent stem cells and their derived cells. The hormetic dose responses were induced by a broad range of chemicals, including pharmaceuticals (eg, metformin), dietary supplements/extracts from medicinal plants (eg, curcumin), and endogenous agents (eg, melatonin). The paper assesses the mechanistic foundations of these induced hormetic dose responses, their therapeutic implications and comparison with hormetic responses in multiple adult and embryonic stem cells.

摘要

本文首次评估了诱导多能干细胞及其衍生细胞中由试剂诱导的兴奋效应剂量反应。这些兴奋效应剂量反应由多种化学物质诱导产生，包括药物（如二甲双胍）、膳食补充剂/药用植物提取物（如姜黄素）和内源性物质（如褪黑素）。本文评估了这些诱导兴奋效应剂量反应的机制基础、它们的治疗意义以及与多种成体干细胞和胚胎干细胞中兴奋效应反应的比较。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/653ae05fda64/10.1177_15593258221075504-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/527e411883fb/10.1177_15593258221075504-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/93afc32c59d5/10.1177_15593258221075504-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/b219cebe0815/10.1177_15593258221075504-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/7befd6630c1d/10.1177_15593258221075504-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/be2c8c29c92d/10.1177_15593258221075504-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/89e8ab3edb7d/10.1177_15593258221075504-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/4d5b6dd84724/10.1177_15593258221075504-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/3595f226ac8f/10.1177_15593258221075504-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/4f84972f70ff/10.1177_15593258221075504-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/653ae05fda64/10.1177_15593258221075504-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/527e411883fb/10.1177_15593258221075504-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/93afc32c59d5/10.1177_15593258221075504-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/b219cebe0815/10.1177_15593258221075504-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/7befd6630c1d/10.1177_15593258221075504-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/be2c8c29c92d/10.1177_15593258221075504-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/89e8ab3edb7d/10.1177_15593258221075504-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/4d5b6dd84724/10.1177_15593258221075504-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/3595f226ac8f/10.1177_15593258221075504-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/4f84972f70ff/10.1177_15593258221075504-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91d1/8905229/653ae05fda64/10.1177_15593258221075504-fig10.jpg

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引用本文的文献

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本文引用的文献

1
Hormesis and dental apical papilla stem cells.兴奋效应与牙乳头干细胞
Chem Biol Interact. 2022 Apr 25;357:109887. doi: 10.1016/j.cbi.2022.109887. Epub 2022 Mar 11.
2
Hormesis and Endothelial Progenitor Cells.兴奋效应与内皮祖细胞
Dose Response. 2022 Feb 23;20(1):15593258211068625. doi: 10.1177/15593258211068625. eCollection 2022 Jan-Mar.
3
Hormesis and embryonic stem cells.胁迫与胚胎干细胞。
Chem Biol Interact. 2022 Jan 25;352:109783. doi: 10.1016/j.cbi.2021.109783. Epub 2021 Dec 18.
4
Human dental pulp stem cells and hormesis.人牙髓干细胞与应激。
Ageing Res Rev. 2022 Jan;73:101540. doi: 10.1016/j.arr.2021.101540. Epub 2021 Dec 8.
5
Hormesis and neural stem cells.胁迫与神经干细胞。
Free Radic Biol Med. 2022 Jan;178:314-329. doi: 10.1016/j.freeradbiomed.2021.12.003. Epub 2021 Dec 4.
6
Hormesis and bone marrow stem cells: Enhancing cell proliferation, differentiation and resilience to inflammatory stress. hormesis 与骨髓干细胞：增强细胞增殖、分化能力并提高对炎症应激的抵抗力。
Chem Biol Interact. 2022 Jan 5;351:109730. doi: 10.1016/j.cbi.2021.109730. Epub 2021 Oct 30.
7
Human periodontal ligament stem cells and hormesis: Enhancing cell renewal and cell differentiation.人牙周韧带干细胞与应激：增强细胞更新和细胞分化。
Pharmacol Res. 2021 Nov;173:105914. doi: 10.1016/j.phrs.2021.105914. Epub 2021 Sep 24.
8
Hormesis and adult adipose-derived stem cells.低剂量效应与成体脂肪源干细胞。
Pharmacol Res. 2021 Oct;172:105803. doi: 10.1016/j.phrs.2021.105803. Epub 2021 Aug 5.
9
Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC) -derived sensory neurons.用人类诱导多能干细胞（iPSC）衍生感觉神经元建立化疗诱导神经毒性模型。
Neurobiol Dis. 2021 Jul;155:105391. doi: 10.1016/j.nbd.2021.105391. Epub 2021 May 11.
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The hormetic dose-response mechanism: Nrf2 activation.激效剂量反应机制：Nrf2 激活。
Pharmacol Res. 2021 May;167:105526. doi: 10.1016/j.phrs.2021.105526. Epub 2021 Mar 2.