Department of Environmental Health Sciences, University of Massachusetts, Morrill I, N344, Amherst, MA 01003, USA.
School of Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing 210044, China.
Ageing Res Rev. 2022 Jan;73:101540. doi: 10.1016/j.arr.2021.101540. Epub 2021 Dec 8.
This paper represents the first assessment of hormetic dose responses by human dental pulp stem cells (hDPSCs) with particular emphasis on cell renewal (proliferation) and differentiation. Hormetic dose responses were commonly reported in this model, encompassing a broad range of chemicals, including principally pharmaceuticals (e.g., metformin and artemisinin), dietary supplements/extracts from medicinal plants (e.g., berberine, N-acetyl-L-cysteine, and ginsenoside Rg1) and endogenous agents (e.g., ATP, TNF-α). The paper assesses mechanistic foundations of the hDPSCs hormetic dose responses for both cell proliferation and cell differentiation, study design considerations, and therapeutic implications.
本文首次评估了牙髓干细胞（hDPSCs）的激动剂剂量反应，特别强调了细胞更新（增殖）和分化。该模型中通常会报告激动剂剂量反应，涵盖了广泛的化学物质，包括主要的药物（例如二甲双胍和青蒿素）、药用植物的膳食补充剂/提取物（例如小檗碱、N-乙酰-L-半胱氨酸和人参皂苷 Rg1）和内源性物质（例如 ATP、TNF-α）。本文评估了 hDPSCs 细胞增殖和细胞分化的激动剂剂量反应的机制基础、研究设计考虑因素和治疗意义。
