Pregnancy Health Research Center, Department of Obstetrics and Gynecology, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Infertility, Faculty of Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Front Endocrinol (Lausanne). 2022 Feb 9;13:778988. doi: 10.3389/fendo.2022.778988. eCollection 2022.
This was a non-blinded randomized controlled study to evaluate whether endometrial irrigation office hysteroscopy during the early follicular phase would lead to a higher level of live birth rates compared to no irrigation in the fresh embryo transfer cycle.
The study was conducted in Tehran university of medical sciences from June 2015 to June 2016. women under the age of 40 with primary infertility without history of previous IVF/ICSI or hysteroscopic examination, were included. Controlled ovarian hyperstimulation was done. Hysteroscopy was performed in the early mid-follicular phase of a stimulation cycle (day 5-7) with a vaginoscopy approach and saline irrigation in hysteroscopy group. Embryo-transfer was done in the same cycle.
228 patients completed their participation in the study. In the fresh cycle, clinical pregnancy rate was 46% in the hysteroscopy group and 40.43% in the control group. (). Live birth rate was 41.28% in the hysteroscopic group and 31.93% in the control group (). For those patients having surplus cryopreserved embryos, after 2 months, a second embryo transfer was performed. The cumulative LBR was 44.05% in the hysteroscopic group and 32.25% in the control group ().
The current study clearly demonstrated a significantly higher cumulative live birth rate in the intervention group.
[https://www.irct.ir/trial/19586], identifier IRCT2016011022795N2.
本研究为非盲随机对照研究，旨在评估在新鲜胚胎移植周期中，与不冲洗相比，在早卵泡期行子宫内膜冲洗宫腔镜检查是否会提高活产率。
该研究于 2015 年 6 月至 2016 年 6 月在德黑兰医科大学进行。纳入年龄小于 40 岁、原发性不孕、无既往 IVF/ICSI 或宫腔镜检查史的患者。行控制性卵巢刺激。在刺激周期的早卵泡中期（第 5-7 天）行宫腔镜检查，经阴道入路，宫腔镜组行生理盐水冲洗。胚胎移植在同一周期进行。
228 例患者完成了研究。在新鲜周期中，宫腔镜组的临床妊娠率为 46%，对照组为 40.43%（）。活产率宫腔镜组为 41.28%，对照组为 31.93%（）。对于那些有剩余冷冻胚胎的患者，在 2 个月后进行第二次胚胎移植。宫腔镜组的累积活产率为 44.05%，对照组为 32.25%（）。
本研究清楚地表明，干预组的累积活产率显著提高。
[https://www.irct.ir/trial/19586]，标识符 IRCT2016011022795N2。
