Uterine Cavity Irrigation With Office Hysteroscopy During Ovarian Stimulation for IVF: A Randomized Controlled Trial.

OBJECTIVE

This was a non-blinded randomized controlled study to evaluate whether endometrial irrigation office hysteroscopy during the early follicular phase would lead to a higher level of live birth rates compared to no irrigation in the fresh embryo transfer cycle.

METHOD

The study was conducted in Tehran university of medical sciences from June 2015 to June 2016. women under the age of 40 with primary infertility without history of previous IVF/ICSI or hysteroscopic examination, were included. Controlled ovarian hyperstimulation was done. Hysteroscopy was performed in the early mid-follicular phase of a stimulation cycle (day 5-7) with a vaginoscopy approach and saline irrigation in hysteroscopy group. Embryo-transfer was done in the same cycle.

RESULTS

228 patients completed their participation in the study. In the fresh cycle, clinical pregnancy rate was 46% in the hysteroscopy group and 40.43% in the control group. (). Live birth rate was 41.28% in the hysteroscopic group and 31.93% in the control group (). For those patients having surplus cryopreserved embryos, after 2 months, a second embryo transfer was performed. The cumulative LBR was 44.05% in the hysteroscopic group and 32.25% in the control group ().

CONCLUSION

The current study clearly demonstrated a significantly higher cumulative live birth rate in the intervention group.

CLINICAL TRIAL REGISTRATION

[https://www.irct.ir/trial/19586], identifier IRCT2016011022795N2.