Zekai Tahir Burak Women's Health Education and Research Hospital, Department of Reproductive Endocrinology, Ankara, Turkey.
Reprod Biomed Online. 2012 Sep;25(3):261-6. doi: 10.1016/j.rbmo.2012.05.013. Epub 2012 Jun 16.
The aim of the study was to evaluate the effect of office hysteroscopy (OH) on pregnancy rate in patients undergoing IVF. A total of 1258 patients attending an IVF clinic with normal hysteroscopic findings were enrolled. The impact of timing of OH before embryo transfer on pregnancy rate was investigated. The women were evaluated in three groups: group 1, OH performed 50 days or less before embryo transfer (n=407), group 2, OH between 51 days to 6 months, (n=280) and group 3, OH more than 6 months before embryo transfer (n=571). The implantation rates were 22.1%, 16.1% and 11.1% in groups 1, 2 and 3, respectively. Overall pregnancy rates were 48.2%, 38.9% and 29.9% in groups 1, 2 and 3, respectively. The clinical pregnancy rates were 45.2%, 34.3% and 27.1% and the live birth rates were 36.9%, 27.9% and 22.6%, respectively. Implantation, pregnancy, clinical pregnancy and live birth rates were significantly higher in group 1 compared with groups 2 and 3 (all P<0.05). OH may improve pregnancy rates, but timing of the procedure is important. The endometrial effect is highest when hysteroscopy is performed 50 days or less before embryo transfer. Office hysteroscopy (OH), which helps the clinician for the evaluation of the uterine cavity before IVF treatment, may affect the pregnancy rates depending on when the procedure is performed. A total of 1258 patients attending an outpatient IVF clinic were enrolled in the study. The women were evaluated in three groups: group 1, OH performed 50 days or less before embryo transfer (n=407), group 2, OH between 51 days to 6 months, (n=280) and group 3, OH more than 6 months before embryo transfer (n=571). The implantation, pregnancy and clinical pregnancy rates were significantly higher in group 1 compared with groups 2 and 3. OH may improve pregnancy rates when performed 50 days or less before embryo transfer.
本研究旨在评估门诊宫腔镜（OH）对接受体外受精（IVF）治疗患者妊娠率的影响。共有 1258 名在 IVF 门诊就诊且宫腔镜检查正常的患者入组。研究了 OH 于胚胎移植前不同时间进行对妊娠率的影响。将这些女性分为三组：第 1 组，OH 于胚胎移植前 50 天或更短时间内进行（n=407）；第 2 组，OH 在 51 天至 6 个月之间进行（n=280）；第 3 组，OH 在胚胎移植前 6 个月以上进行（n=571）。第 1、2 和 3 组的种植率分别为 22.1%、16.1%和 11.1%。第 1、2 和 3 组的总妊娠率分别为 48.2%、38.9%和 29.9%。第 1、2 和 3 组的临床妊娠率分别为 45.2%、34.3%和 27.1%，活产率分别为 36.9%、27.9%和 22.6%。与第 2 组和第 3 组相比，第 1 组的种植率、妊娠率、临床妊娠率和活产率均显著更高（均 P<0.05）。OH 可能提高妊娠率，但操作时机很重要。当 OH 于胚胎移植前 50 天或更短时间内进行时，子宫内膜的作用最高。门诊宫腔镜（OH）有助于临床医生在接受 IVF 治疗前评估子宫腔，其对妊娠率的影响取决于操作时间。本研究共纳入 1258 名在门诊 IVF 诊所就诊的患者。将这些女性分为三组：第 1 组，OH 于胚胎移植前 50 天或更短时间内进行（n=407）；第 2 组，OH 在 51 天至 6 个月之间进行（n=280）；第 3 组，OH 在胚胎移植前 6 个月以上进行（n=571）。与第 2 组和第 3 组相比，第 1 组的种植率、妊娠率和临床妊娠率均显著更高。当 OH 于胚胎移植前 50 天或更短时间内进行时，可能会提高妊娠率。
