Goudarzi Gholamreza, Hasanvand Yaser, Rezaei Faranak, Delfani Somayeh
Department of Microbiology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Iran J Microbiol. 2021 Dec;13(6):817-823. doi: 10.18502/ijm.v13i6.8086.
Recently, the rise of methicillin-resistant (MRSA) isolated from hospital healthcare workers (HCWs) and various infectious samples has become one of the main concerns in hospital settings. Therefore, epidemiological studies are necessary to monitor antibiotic resistance patterns in each region and to study the pathogenesis of this strain to control infections.
In this cross-sectional study, a total of 100 isolates, including 50 isolates obtained from the anterior nares of healthcare workers, as well as 50 other isolates cultured from the various clinical specimens from the referral hospitals in Khorramabad (West of Iran) were tested. All isolates were examined to determine antibiotic resistance pattern, and the presence of staphylococcal enterotoxin A (), staphylococcal enterotoxin B () and genes.
The gene was found among 36% (18/50) of the clinical isolates (CSIs) and 14% (7/50) of nasal isolates (NSIs), with statistically significant difference (X2 = 6.53; p = 0.011). The difference between the frequency rate of gene among MRSA strains isolated from clinical specimens (46.6%, 7/15) was significant compared to strains isolated from nostrils (14.3%, 1/7) (X2 = 3.85; p = 0.049).
The frequency of , and genes among the clinical samples was more than strains isolated from the nostrils of healthcare personnel.
近期，从医院医护人员（HCWs）及各类感染样本中分离出的耐甲氧西林金黄色葡萄球菌（MRSA）的增多，已成为医院环境中的主要关注点之一。因此，开展流行病学研究对于监测各地区的抗生素耐药模式以及研究该菌株的发病机制以控制感染十分必要。
在这项横断面研究中，共检测了100株分离株，其中包括从医护人员前鼻孔获取的50株分离株，以及从伊朗西部霍拉马巴德转诊医院的各类临床标本中培养出的50株其他分离株。对所有分离株进行检测以确定抗生素耐药模式，以及葡萄球菌肠毒素A（）、葡萄球菌肠毒素B（）和基因的存在情况。
在36%（18/50）的临床分离株（CSIs）和14%（7/50）的鼻腔分离株（NSIs）中发现了基因，差异具有统计学意义（X2 = 6.53；p = 0.011）。从临床标本中分离出的MRSA菌株中基因的频率（46.6%，7/15）与从鼻孔分离出的菌株（14.3%，1/7）相比差异显著（X2 = 3.85；p = 0.049）。
临床样本中、和基因的频率高于从医护人员鼻孔分离出的菌株。
