A comparative characterization of nasal and clinical isolates of from west of Iran.

BACKGROUND AND OBJECTIVES

Recently, the rise of methicillin-resistant (MRSA) isolated from hospital healthcare workers (HCWs) and various infectious samples has become one of the main concerns in hospital settings. Therefore, epidemiological studies are necessary to monitor antibiotic resistance patterns in each region and to study the pathogenesis of this strain to control infections.

MATERIALS AND METHODS

In this cross-sectional study, a total of 100 isolates, including 50 isolates obtained from the anterior nares of healthcare workers, as well as 50 other isolates cultured from the various clinical specimens from the referral hospitals in Khorramabad (West of Iran) were tested. All isolates were examined to determine antibiotic resistance pattern, and the presence of staphylococcal enterotoxin A (), staphylococcal enterotoxin B () and genes.

RESULTS

The gene was found among 36% (18/50) of the clinical isolates (CSIs) and 14% (7/50) of nasal isolates (NSIs), with statistically significant difference (X2 = 6.53; p = 0.011). The difference between the frequency rate of gene among MRSA strains isolated from clinical specimens (46.6%, 7/15) was significant compared to strains isolated from nostrils (14.3%, 1/7) (X2 = 3.85; p = 0.049).

CONCLUSION

The frequency of , and genes among the clinical samples was more than strains isolated from the nostrils of healthcare personnel.