Department of Microbiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
Mol Biol Rep. 2024 May 25;51(1):686. doi: 10.1007/s11033-024-09580-9.
This research study was undertaken to investigate antimicrobial resistance patterns and the prevalence of hospital-acquired infections (HAIs). The study focuses on common microorganisms responsible for HAIs and explores emerging challenges posed by antimicrobial drug-resistant isolates.
A comprehensive analysis of 123 patients with HAIs, hospitalized in surgical department and intensive care unit (ICU) at Imam Khomeini Hospital, Ilam, Iran, was conducted over a six-month period. Pathogenic bacterial isolates, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA), were isolated and subjected to antibiotic susceptibility testing.
The study findings revealed a significant prevalence of multidrug-resistant (MDR) isolates, of which 73.3% were MRSA. Notably, 6.7% of S. aureus isolates exhibited resistance to vancomycin, indicating the emergence of VRSA. Respiratory infections were identified as the most prevalent HAI, constituting 34.67% of cases, often arising from extended ICU stays and invasive surgical procedures. Furthermore, patients aged 60 and above, particularly those associated with MDR, exhibited higher vulnerability to HAI.
This research sheds light on the intricate interplay between drug resistance and HAI, highlighting the imperative role of rational antibiotic use and infection control in addressing this critical healthcare challenge.
本研究旨在调查抗菌药物耐药模式和医院获得性感染（HAIs）的流行情况。本研究关注引起 HAI 的常见微生物，并探讨由抗菌药物耐药分离株引起的新出现的挑战。
在伊朗伊拉姆伊玛目霍梅尼医院外科病房和重症监护病房（ICU）对 123 例 HAI 患者进行了为期六个月的综合分析。分离并对致病性细菌分离株（包括耐甲氧西林金黄色葡萄球菌（MRSA）和万古霉素耐药金黄色葡萄球菌（VRSA））进行了抗生素药敏试验。
研究结果显示，耐多药（MDR）分离株的流行率显著，其中 73.3%为 MRSA。值得注意的是，6.7%的金黄色葡萄球菌分离株对万古霉素耐药，表明 VRSA 的出现。呼吸道感染是最常见的 HAI，占 34.67%，通常源于 ICU 住院时间延长和侵入性手术。此外，年龄在 60 岁及以上的患者，特别是与 MDR 相关的患者，更容易发生 HAI。
本研究揭示了耐药性和 HAI 之间的复杂相互作用，强调了合理使用抗生素和感染控制在应对这一重大医疗保健挑战中的重要作用。
