Chutná J, Holán V, Sládecek M, Hasek M
Folia Biol (Praha). 1986;32(2):154-8.
Permanent tolerance of the entire H-2 complex incompatible B10 skin allografts was induced in adult B10.A mice by post-transplant treatment. Recipient mice were treated with heterologous antithymocyte serum (ATS) and specific tissue extracts or monoclonal antibodies anti-Thy-1.2. Combination of treatments with the specific tissue extracts and monoclonal antibodies leads to a high degree of tolerance in the majority of ATS-treated animals. Results thus show that it is possible to induce long-term tolerance of the entire H-2 complex incompatible skin allografts in mice using specific and non-specific immunosuppression given in the post-transplant period.
通过移植后处理，在成年B10.A小鼠中诱导出对整个H-2复合体不相容的B10皮肤同种异体移植物的永久性耐受。受体小鼠用异种抗胸腺细胞血清（ATS）和特定组织提取物或抗Thy-1.2单克隆抗体进行处理。特定组织提取物和单克隆抗体联合处理可使大多数接受ATS处理的动物产生高度耐受。因此，结果表明，在移植后给予特异性和非特异性免疫抑制，有可能在小鼠中诱导出对整个H-2复合体不相容皮肤同种异体移植物的长期耐受。
