Gobyzov Oleg A, Ryabov Mikhail N, Yankova Viktoriya G, Gribanova Svetlana V, Slonskaya Tatiana K, Udyanskaya Irina L, Zhukova Anna A, Grigoryeva Viktoriya Yu
Laboratory of Transfer Processes in Multiphase Systems, S. S. Kutateladze Institute of Thermophysics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Chair of Analytical, Physical and Colloid Chemistry, The Institute of Pharmacy, I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
J Adv Pharm Technol Res. 2022 Jan-Mar;13(1):30-37. doi: 10.4103/japtr.japtr_240_21. Epub 2022 Jan 21.
Metered-dose nasal sprays (MDNS) are the most widely used for treating rhinitis. Medicinal preparations in the pharmaceutical market vary in their characteristics. To identify the most effective drug, it is necessary to compare the preparations regarding various parameters. The purpose of the research was to compare oxymetazoline MDNS of different brands regarding their dispersion qualities. To that end, nine oxymetazoline sprays available in the Russian market were chosen and analyzed considering their dynamic characteristics and the spraying dispersion composition. The research was conducted with the shadow photography method, the selection of which was justified by its simplicity, the possibilities for detecting the spray jet composition, the process of its formation in dynamics, and the possibility for measuring droplets of all forms. Momentary images of spray activation phases, as well as an averaged image of 100 shots of the spraying main phase, were obtained. According to a range of characteristics, such as spraying duration, a cone angle and cone structure, all the preparations were grouped into three categories. It was found out that the sprays from Group 2 had the best dynamic rates of dispersion, with Vicks Sinex having the best results. Regarding the distribution of particles of different size, the most optimal composition was found for the drugs from Group 2, particularly, Vicks Sinex and Afrin preparations. Hence, Vicks Sinex spraying regimen and microsprayer design were found the most effective for delivering the medicinal substance to the destination.
定量鼻喷雾剂（MDNS）是治疗鼻炎最广泛使用的药物。医药市场上的药物制剂各有特点。为了确定最有效的药物，有必要在各种参数方面对制剂进行比较。本研究的目的是比较不同品牌的羟甲唑啉MDNS的分散质量。为此，选择了俄罗斯市场上现有的九种羟甲唑啉喷雾剂，并从其动态特性和喷雾分散成分方面进行分析。本研究采用阴影摄影法进行，其选择的合理性在于其简单性、检测喷雾射流成分的可能性、其动态形成过程以及测量各种形式液滴的可能性。获得了喷雾激活阶段的瞬间图像以及喷雾主阶段100次喷射的平均图像。根据一系列特性，如喷雾持续时间、锥角和锥结构，将所有制剂分为三类。结果发现，第2组喷雾剂的动态分散率最佳，其中Vicks Sinex的效果最佳。关于不同大小颗粒的分布，发现第2组药物，特别是Vicks Sinex和Afrin制剂的成分最为理想。因此，发现Vicks Sinex的喷雾方案和微喷雾器设计在将药物输送到目标部位方面最为有效。
