Inzani Frediano, Arciuolo Damiano, Angelico Giuseppe, Santoro Angela, Travaglino Antonio, D'Alessandris Nicoletta, Scaglione Giulia, Valente Michele, Cianfrini Federica, Raffone Antonio, Zannoni Gian Franco
Unità di Ginecopatologia e Patologia Mammaria, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.
Front Oncol. 2022 Feb 10;12:814989. doi: 10.3389/fonc.2022.814989. eCollection 2022.
In the last decades, several new therapeutic strategies have been introduced in the field of gynecologic oncology. These include neoadjuvant chemotherapy for high-grade serous tubo-ovarian carcinoma, hormonal fertility-sparing strategies for endometrial cancer, pressurized intraperitoneal aerosol chemotherapy (PIPAC) for surgically incurable peritoneal metastasis, and neoadjuvant treatments for locally advanced cervical carcinomas. All these recent advances lead to the development of novel scoring systems for the evaluation of pathological response related to specific treatments. In this regard, pathological evaluation of the morphological modifications related to these treatments and the definition of a tumor regression grading score have been introduced in clinical practice in order to achieve a more efficient prognostic stratification of patients affected by gynecological malignancies. The aim of the present paper is to provide a detailed review on the post-treatment pathological scoring systems in patients affected by gynecological malignancies.
在过去几十年里，妇科肿瘤学领域引入了几种新的治疗策略。这些策略包括针对高级别浆液性输卵管卵巢癌的新辅助化疗、针对子宫内膜癌的保留生育功能的激素治疗策略、针对手术无法治愈的腹膜转移的加压腹腔内气溶胶化疗（PIPAC）以及针对局部晚期宫颈癌的新辅助治疗。所有这些最新进展促使开发了用于评估与特定治疗相关的病理反应的新型评分系统。在这方面，为了对妇科恶性肿瘤患者进行更有效的预后分层，已将与这些治疗相关的形态学改变的病理评估以及肿瘤消退分级评分的定义引入临床实践。本文的目的是对妇科恶性肿瘤患者治疗后的病理评分系统进行详细综述。
