肿瘤中的丝氨酸蛋白酶抑制剂Kazal型家族成员：潜在的治疗靶点。
SPINKs in Tumors: Potential Therapeutic Targets.
作者信息
Liao Chengcheng, Wang Qian, An Jiaxing, Zhang Minglin, Chen Jie, Li Xiaolan, Xiao Linlin, Wang Jiajia, Long Qian, Liu Jianguo, Guan Xiaoyan
机构信息
Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, China.
Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical University, Zunyi, China.
出版信息
Front Oncol. 2022 Feb 11;12:833741. doi: 10.3389/fonc.2022.833741. eCollection 2022.
The serine protease inhibitor Kazal type (SPINK) family includes SPINK1-14 and is the largest branch in the serine protease inhibitor family. SPINKs play an important role in pancreatic physiology and disease, sperm maturation and capacitation, Nager syndrome, inflammation and the skin barrier. Evidence shows that the unregulated expression of SPINK1, 2, 4, 5, 6, 7, and 13 is closely related to human tumors. Different SPINKs exhibit various regulatory modes in different tumors and can be used as tumor prognostic markers. This article reviews the role of SPINK1, 2, 4, 5, 6, 7, and 13 in different human cancer processes and helps to identify new cancer treatment targets.
丝氨酸蛋白酶抑制剂Kazal型（SPINK）家族包括SPINK1 - 14，是丝氨酸蛋白酶抑制剂家族中最大的分支。SPINKs在胰腺生理与疾病、精子成熟与获能、纳格综合征、炎症及皮肤屏障中发挥重要作用。有证据表明，SPINK1、2、4、5、6、7和13的表达失调与人类肿瘤密切相关。不同的SPINKs在不同肿瘤中表现出多种调控模式，可作为肿瘤预后标志物。本文综述了SPINK1、2、4、5、6、7和13在不同人类癌症进程中的作用，有助于确定新的癌症治疗靶点。
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