Sawuer Reziya, Wu Chunyu, Sun Zhenping, Liu Sheng
Department of Breast Surgery (Integrated Traditional and Western Medicine), Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Oncol. 2022 Feb 10;12:833742. doi: 10.3389/fonc.2022.833742. eCollection 2022.
The etiology and pathology of granulomatous mastitis (GLM) are still unknown. Expert consensus on the treatment of GLM has not been developed. The objective of this study is to study the effectiveness of traditional Chinese medicine (TCM) combined with surgery in treating GLM.
A retrospective cohort study was implemented at Longhua Hospital of Shanghai University of Traditional Chinese Medicine in China between September 2019 and August 2021. Female patients were included according to the propensity-score matching (PSM) method and balanced according to age and BMI. Patients with GLM diagnosed by pathology and a course of disease ≥ 6 months were included in this trial. Patients were divided into the TCM alone group or TCM + surgery group.
In total, 168 female patients were assessed and 102 patients were included in the study after PSM (51 in the TCM group and 51 in the TCM + surgery group). The average age of the patients was 32 years (21-47 years). There was no significant baseline characteristics difference between two groups after PSM. The suppuration rate in the TCM + surgery group was less than that in the TCM group (64.7% 83.35%, P < 0.05), and the TCM + surgery group had a higher 9-month cure rate than the TCM group (86.3% 52.9%, P < 0.05). The full course of disease in the TCM + surgery group was shorter than that in the TCM group (253.9 ± 117.3 days 332.5 ± 111.6 days, P < 0.05).
TCM combined with surgery can improve the cure rate and shorten the full course of GLM treatment, indicating surgery should be integrated in the clinical management of GLM.
肉芽肿性乳腺炎（GLM）的病因和病理仍不清楚。尚未形成关于GLM治疗的专家共识。本研究的目的是探讨中药联合手术治疗GLM的有效性。
于2019年9月至2021年8月在中国上海中医药大学附属龙华医院开展一项回顾性队列研究。根据倾向得分匹配（PSM）方法纳入女性患者，并根据年龄和体重指数进行平衡。纳入经病理诊断为GLM且病程≥6个月的患者。将患者分为单纯中药组或中药+手术组。
共评估了168例女性患者，经PSM后102例患者纳入研究（中药组51例，中药+手术组51例）。患者的平均年龄为32岁（21 - 47岁）。PSM后两组间基线特征无显著差异。中药+手术组的化脓率低于中药组（64.7%对83.35%，P < 0.05），中药+手术组9个月的治愈率高于中药组（86.3%对52.9%，P < 0.05）。中药+手术组的病程短于中药组（253.9±117.3天对332.5±111.6天，P < 0.05）。
中药联合手术可提高GLM的治愈率并缩短治疗全程，表明手术应纳入GLM的临床管理中。
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