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保乳手术后的肉芽肿——三例报告

Granuloma after breast conserving surgery-a report of three cases.

作者信息

Ichinose Yuki, Kosaka Yoshimasa, Saeki Toshiaki, Fujimoto Akihiro, Nukui Asami, Asano Aya, Shimada Hiroko, Matsuura Kazuo, Hasebe Takahiro, Osaki Akihiko

机构信息

Department of Breast Oncology, Saitama Medical University International Medical Center, Saitama, Japan.

出版信息

J Surg Case Rep. 2021 Jun 4;2021(6):rjab199. doi: 10.1093/jscr/rjab199. eCollection 2021 Jun.

DOI:10.1093/jscr/rjab199
PMID:34104403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8177901/
Abstract

Granulomatous mastitis is a rare breast disease that is categorized as a benign tumor with chronic inflammation. Since the cause of the chronic inflammation is usually unknown, it is sometimes called idiopathic granulomatous mastitis (IGM). Although imaging modalities, such as ultrasound, magnetic resonance imaging and mammography can detect tumors, they are sometimes unable to differentiate between benign and malignant tumors. In such cases, biopsy is needed to make a correct diagnosis. We experienced three cases of IGM after breast conserving surgery in breast cancer patients in whom we needed to rule out recurrence of breast cancer. In our cases, tumorectomy was performed in two cases for pathological diagnosis, since neither biopsy nor cytology was able to reveal a conclusive pathological diagnosis. Our management of these three cases might suggest the appropriate management of granulomatous tumors after breast conserving surgery in breast cancer survivors.

摘要

肉芽肿性乳腺炎是一种罕见的乳腺疾病,被归类为伴有慢性炎症的良性肿瘤。由于慢性炎症的病因通常不明,它有时被称为特发性肉芽肿性乳腺炎(IGM)。尽管超声、磁共振成像和乳腺X线摄影等影像学检查手段能够检测出肿瘤,但有时无法区分良性和恶性肿瘤。在这种情况下,需要进行活检以做出正确诊断。我们遇到了3例乳腺癌患者保乳手术后发生IGM的病例,在这些病例中我们需要排除乳腺癌复发。在我们的病例中,有2例进行了肿瘤切除术以进行病理诊断,因为活检和细胞学检查均未能得出确切的病理诊断。我们对这3例病例的处理可能为乳腺癌幸存者保乳手术后肉芽肿性肿瘤的适当处理提供了参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d3f/8177901/6bfd8382794c/rjab199f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d3f/8177901/75e8f8192c5d/rjab199f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d3f/8177901/352851e287d6/rjab199f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d3f/8177901/3924b7954417/rjab199f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d3f/8177901/6bfd8382794c/rjab199f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d3f/8177901/75e8f8192c5d/rjab199f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d3f/8177901/352851e287d6/rjab199f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d3f/8177901/3924b7954417/rjab199f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d3f/8177901/6bfd8382794c/rjab199f4.jpg

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本文引用的文献

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Prognostic study for isolated local recurrence operated with salvage excision in hormone-receptor-positive patients with invasive breast cancer after primary breast surgery.激素受体阳性浸润性乳腺癌患者在初次乳腺手术后接受挽救性切除治疗的孤立性局部复发的预后研究。
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Evaluation of 2014 margin guidelines on re-excision and recurrence rates after breast conserving surgery: A multi-institution retrospective study.2014 年切缘指南对保乳手术后再次切除和复发率的评估:一项多机构回顾性研究。
Breast. 2020 Jun;51:29-33. doi: 10.1016/j.breast.2020.02.013. Epub 2020 Mar 6.
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Breast Biopsy During Post-treatment Surveillance of Screen-Detected Breast Cancer Patients Yields High Rates of Benign Findings.
乳腺 X 线筛查检出乳腺癌患者的治疗后随访中活检良性率高。
Ann Surg Oncol. 2020 Aug;27(8):2689-2697. doi: 10.1245/s10434-020-08259-2. Epub 2020 Feb 25.
4
Differentiation between idiopathic granulomatous mastitis and invasive breast carcinoma, both presenting with non-mass enhancement without rim-enhanced masses: The value of whole-lesion histogram and texture analysis using apparent diffusion coefficient.特发性肉芽肿性乳腺炎与浸润性乳腺癌的鉴别诊断,两者均表现为无肿块强化且无环形强化肿块:应用表观扩散系数的全病变直方图和纹理分析的价值。
Eur J Radiol. 2020 Feb;123:108782. doi: 10.1016/j.ejrad.2019.108782. Epub 2019 Dec 11.
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Idiopathic Granulomatous Mastitis with Skin Rupture: A Retrospective Cohort Study of 200 Patients Who Underwent Surgical and Nonsurgical Treatment.特发性肉芽肿性乳腺炎伴皮肤破溃:200 例手术与非手术治疗患者的回顾性队列研究。
J Invest Surg. 2021 Jul;34(7):810-815. doi: 10.1080/08941939.2019.1696905. Epub 2019 Dec 10.
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Re-evaluating if observation continues to be the best management of idiopathic granulomatous mastitis.重新评估观察是否仍然是特发性肉芽肿性乳腺炎的最佳治疗方法。
Surgery. 2019 Dec;166(6):1176-1180. doi: 10.1016/j.surg.2019.06.030. Epub 2019 Aug 8.